Kaynakça

Tags

Kitaplar

Ne Yiyeceğimi Şaşırdım. Dr Banu Taşcı Fresko & Esra Kaftan Doğan Kitap, 6. Baskı 2021
- Histamine Intolerance: Histamine and Seasickness. Springer 2015 Reinhart Jarisch (Editor)
- Artık Ağrımasın. Dr Banu Taşcı Fresko, Paloma Yayınevi, 5. Baskı 2021.
- Beynini Doğru Besle. Dr Banu Taşcı Fresko, Hayy Kitap Yayınevi, 7. Baskı 2020.
- Koronavirüs Enfeksiyonu ve Sonrası Büyük Yorgunluk. Dr Banu Taşcı Fresko & Dr Sıla Akhan, Akademisyen Yayınevi, 1. Baskı 2021
- Histamine intolerance food list.The Histamine Heroes. 2021

Literatür

Bir nöroloğun histamin ile olan çetrefilli hikayesi

Szaflarska-Popławska, A. The Role of the Gluten-Free Diet in the Management of Seronegative Enteropathy. Nutrients 2021, 13, 4027. https://doi.org/10.3390/nu1311402
Tahıl Beyin Dr David Perlmutter Pegasus Yayınları 2017

Histamin intoleransı/ tanı/ tedavi

Reese I, Ballmer-Weber B, Beyer K, Dölle-Bierke S, Kleine-Tebbe J, Klimek L, Lämmel S, Lepp U, Saloga J, Schäfer C, Szepfalusi Z, Treudler R, Werfel T, Zuberbier T, Worm M. Guideline on management of suspected adverse reactions to ingested histamine: Guideline of the German Society for Allergology and Clinical Immunology (DGAKI), the Society for Pediatric Allergology and Environmental Medicine (GPA), the Medical Association of German Allergologists (AeDA) as well as the Swiss Society for Allergology and Immunology (SGAI) and the Austrian Society for Allergology and Immunology (ÖGAI). Allergol Select. 2021 Oct 5;5:305-314. doi: 10.5414/ALX02269E. PMID: 34651098; PMCID: PMC8511827.
Maintz L, Novak N. Histamine and histamine intolerance. Am J Clin Nutr. 2007 May;85(5):1185-96. doi: 10.1093/ajcn/85.5.1185. PMID: 17490952.
Shulpekova YO, Nechaev VM, Popova IR, Deeva TA, Kopylov AT, Malsagova KA, Kaysheva AL, Ivashkin VT. Food Intolerance: The Role of Histamine. Nutrients. 2021 Sep 15;13(9):3207. doi: 10.3390/nu13093207. PMID: 34579083; PMCID: PMC8469513.
Nazar W, Plata-Nazar K, Sznurkowska K, Szlagatys-Sidorkiewicz A. Histamine Intolerance in Children: A Narrative Review. Nutrients. 2021 Apr 28;13(5):1486. doi: 10.3390/nu13051486. PMID: 33924863; PMCID: PMC8144954.
Reese I. Nutrition therapy for adverse reactions to histamine in food and beverages. Allergol Select. 2018;2(1):56-61. Published 2018 Sep 1. doi:10.5414/ALX386
Hrubisko M, Danis R, Huorka M, Wawruch M. Histamine Intolerance-The More We Know the Less We Know. A Review. Nutrients. 2021 Jun 29;13(7):2228. doi: 10.3390/nu13072228. PMID: 34209583; PMCID: PMC8308327.
Comas-Basté O, Sánchez-Pérez S, Veciana-Nogués MT, Latorre-Moratalla M, Vidal-Carou MDC. Histamine Intolerance: The Current State of the Art. Biomolecules. 2020;10(8):1181. Published 2020 Aug 14. doi:10.3390/biom10081181
https://www.histaminintoleranz.ch/downloads/SIGHI-Leaflet_HistamineEliminationDiet.pdf
https://doi.org/10.3390/nu13072228
Sánchez-Pérez, S.; Comas-Basté, O.; Veciana-Nogués, M.T.; Latorre-Moratalla, M.L.; Vidal-Carou, M.C. Low-Histamine Diets: Is the Exclusion of Foods Justified by Their Histamine Content? Nutrients 2021, 13, 1395. https://doi.org/10.3390/nu13051395
San Mauro Martin I., Brachero S., Garicano Vilar E. Histamine intolerance and dietary management: A complete review. Allergol. Immunopathol. 2016;44:475–483. doi: 10.1016/j.aller.2016.04.015.

Histamin intoleransı bulguları/belirtileri

Yalancı alerji

Kacik J, Wróblewska B, Lewicki S, Zdanowski R, Kalicki B. Serum Diamine Oxidase in Pseudoallergy in the Pediatric Population. Adv Exp Med Biol. 2018;1039:35-44. doi: 10.1007/5584_2017_81. PMID: 28 König B, Koch AN, Bellanti JA. Studies of mitochondrial and nuclear DNA released from food allergen-activated neutrophils. Implications for non-IgE food allergy. Allergy Asthma Proc. 2021 May 1;42(3):e59-e70. doi: 10.2500/aap.2021.42.210021. PMID: 33980341.
Guida B, De Martino CD, De Martino SD, Tritto G, Patella V, Trio R, D’Agostino C, Pecoraro P, D’Agostino L. Histamine plasma levels and elimination diet in chronic idiopathic urticaria. Eur J Clin Nutr. 2000 Feb;54(2):155-8. doi: 10.1038/sj.ejcn.1600911. PMID: 10694787.
Voss M, Kotrba J, Gaffal E, Katsoulis-Dimitriou K, Dudeck A. Mast Cells in the Skin: Defenders of Integrity or Offenders in Inflammation? Int J Mol Sci. 2021 Apr 27;22(9):4589. doi: 10.3390/ijms22094589. PMID: 33925601; PMCID: PMC8123885.
Schnedl WJ, Lackner S, Enko D, Schenk M, Holasek SJ, Mangge H. Evaluation of symptoms and symptom combinations in histamine intolerance. Intest Res. 2019;17(3):427-433. doi:10.5217/ir.2018.00152
Lugović-Mihić L, Seserko A, Duvancić T, Situm M, Mihić J. Intolerancija na histamin–koje su moguće posljedice na kozi? [Histamine intolerance–possible dermatologic sequences]. Acta Med Croatica. 2012 Dec;66(5):375-81. Croatian. PMID: 23814966.

Mide bağırsak yakınmaları

Schnedl WJ, Enko D. Considering histamine in functional gastrointestinal disorders. Crit Rev Food Sci Nutr. 2021;61(17):2960-2967. doi: 10.1080/10408398.2020.1791049. Epub 2020 Jul 9. PMID: 32643952.
Rosell-Camps A, Zibetti S, Pérez-Esteban G, Vila-Vidal M, Ferrés-Ramis L, García-Teresa-García E. Histamine intolerance as a cause of chronic digestive complaints in pediatric patients. Rev Esp Enferm Dig. 2013 Apr;105(4):201-6. doi: 10.4321/s1130-01082013000400004. PMID: 23859448.
Hoffmann, K.M., Gruber, E., Deutschmann, A., et al., Histamine intolerance in children with chronic abdominal pain, Arch. Dis. Child., 2013, vol. 98, no. 10, pp. 832—833.

Nörolojik yakınmalar

Cheng L, Liu J, Chen Z. The Histaminergic System in Neuropsychiatric Disorders. Biomolecules. 2021 Sep 11;11(9):1345. doi: 10.3390/biom11091345. PMID: 34572558; PMCID: PMC8467868.

Baş ağrısı

Conti P, D’Ovidio C, Conti C, et al. Progression in migraine: role of mast cells and pro-inflammatory and anti-inflammatory cytokines. Eur J Pharmacol. 2019;844:87-94.
Izquierdo-Casas J, Comas-Basté O, Latorre-Moratalla ML, Lorente-Gascón M, Duelo A, Vidal-Carou MC, Soler-Singla L. Low serum diamine oxidase (DAO) activity levels in patients with migraine. J Physiol Biochem. 2018 Feb;74(1):93-99. doi: 10.1007/s13105-017-0571-3. Epub 2017 Jun 17. PMID: 28624934.
Izquierdo-Casas J, Comas-Basté O, Latorre-Moratalla ML, Lorente-Gascón M, Duelo A, Soler-Singla L, Vidal-Carou MC. Diamine oxidase (DAO) supplement reduces headache in episodic migraine patients with DAO deficiency: A randomized double-blind trial. Clin Nutr. 2019 Feb;38(1):152-158. doi: 10.1016/j.clnu.2018.01.013. Epub 2018 Feb 15. PMID: 29475774.
García-Martín E, Martínez C, Serrador M, Alonso-Navarro H, Ayuso P, Navacerrada F, Agúndez JA, Jiménez-Jiménez FJ. Diamine oxidase rs10156191 and rs2052129 variants are associated with the risk for migraine. Headache. 2015 Feb;55(2):276-86. doi: 10.1111/head.12493. Epub 2015 Jan 22. PMID: 25612138.
Wantke F, Götz M, Jarisch R. Histamine-free diet: treatment of choice for histamine-induced food intolerance and supporting treatment for chronic headaches. Clin Exp Allergy. 1993 Dec;23(12):982-5. doi: 10.1111/j.1365-2222.1993.tb00287.x. PMID: 10779289
Jarisch R, Wantke F. Wine and headache. Int Arch Allergy Immunol. 1996 May;110(1):7-12. doi: 10.1159/000237304. PMID: 8645981.
Zhao Z, Jin H, Yin Y, et al. Association of Migraine with Its Comorbidities and Food Specific Immunoglobulin G Antibodies and Inflammatory Cytokines: Cross-Sectional Clinical Research. J Pain Res. 2021;14:2359-2368. Published 2021 Aug 5. doi:10.2147/JPR.S316619

Kronik ağrı /fibromiyalji

Mai L, Liu Q, Huang F, He H, Fan W. Involvement of Mast Cells in the Pathophysiology of Pain. Front Cell Neurosci. 2021 Jun 10;15:665066. doi: 10.3389/fncel.2021.665066. PMID: 34177465; PMCID: PMC8222580.
Obara I, Telezhkin V, Alrashdi I, Chazot PL. Histamine, histamine receptors, and neuropathic pain relief. Br J Pharmacol. 2020 Feb;177(3):580-599. doi: 10.1111/bph.14696. Epub 2019 Jun 7. PMID: 31046146; PMCID: PMC7012972.
Skaper SD, Facci L, Giusti P. Mast cells, glia and neuroinflammation: partners in crime?. Immunology. 2014;141(3):314-327. doi:10.1111/imm.12170

Baş dönmesi ve kulak çınlaması

Lacour M, Sterkers O. Histamine and betahistine in the treatment of vertigo: elucidation of mechanisms of action. CNS Drugs. 2001;15(11):853-70. doi: 10.2165/00023210-200115110-00004. PMID: 11700150.
Qin D, Zhang H, Wang J, Hong Z. Histamine H4 receptor gene polymorphisms: a potential contributor to Meniere disease. BMC Med Genomics. 2019 May 27;12(1):71. doi: 10.1186/s12920-019-0533-4. PMID: 31133025; PMCID: PMC6537354.
Zhang XY, Yu L, Zhuang QX, Peng SY, Zhu JN, Wang JJ. Postsynaptic mechanisms underlying the excitatory action of histamine on medial vestibular nucleus neurons in rats. Br J Pharmacol. 2013 Sep;170(1):156-69. doi: 10.1111/bph.12256. PMID: 23713466; PMCID: PMC3764857.
Hagenow J, Stark H. Histamine H₄ Receptor Antagonists: A New Approach for Tinnitus Treatment? Recent Pat CNS Drug Discov. 2015;10(1):6-9. doi: 10.2174/1574889810666150424161907. PMID: 25909438.
Jones TM, Trabold M, Plante F, Cheetham BM, Earis JE. Objective assessment of hoarseness by measuring jitter. Clin Otolaryngol Allied Sci. 2001 Feb;26(1):29-32. doi: 10.1046/j.1365-2273.2001.00413.x. PMID: 11298163.

Kaygı bozukluğu

Nautiyal KM, Ribeiro AC, Pfaff DW, Silver R. Brain mast cells link the immune system to anxiety-like behavior. Proc Natl Acad Sci U S A. 2008 Nov 18;105(46):18053-7. doi: 10.1073/pnas.0809479105. Epub 2008 Nov 11. PMID: 19004805; PMCID: PMC2584714.
Ikarashi Y, Yuzurihara M. Experimental anxiety induced by histaminergics in mast cell-deficient and congenitally normal mice. Pharmacol Biochem Behav. 2002 May;72(1-2):437-41. doi: 10.1016/s0091-3057(02)00708-6. PMID: 11900817.

Ortostatik/kardiyolojik/ solunulum bulguları

Laura Maintz, Natalija Novak, Histamine and histamine intolerance, The American Journal of Clinical Nutrition, Volume 85, Issue 5, May 2007, Pages 1185–1196, https://doi.org/10.1093/ajcn/85.5.1185
Ashina K, Tsubosaka Y, Nakamura T, et al. Histamine Induces Vascular Hyperpermeability by Increasing Blood Flow and Endothelial Barrier Disruption In Vivo. PLoS One. 2015;10(7):e0132367. Published 2015 Jul 9. doi:10.1371/journal.pone.0132367
Bedarida G, Bushell E, Blaschke TF, Hoffman BB. H1- and H2-histamine receptor-mediated vasodilation varies with aging in humans. Clin Pharmacol Ther. 1995 Jul;58(1):73-80. doi: 10.1016/0009-9236(95)90074-8. PMID: 7628185.
Sandilands EA, Crowe J, Cuthbert H, Jenkins PJ, Johnston NR, Eddleston M, Bateman DN, Webb DJ. Histamine-induced vasodilatation in the human forearm vasculature. Br J Clin Pharmacol. 2013 Nov;76(5):699-707. doi: 10.1111/bcp.12110. PMID: 23488545; PMCID: PMC3853529.
Afshari R, Maxwell SR, Webb DJ, Bateman DN. Morphine is an arteriolar vasodilator in man. Br J Clin Pharmacol. 2009 Apr;67(4):386-93. doi: 10.1111/j.1365-2125.2009.03364.x. PMID: 19371311; PMCID: PMC2679101.
Scallan JP, Davis MJ. Itching for answers: how histamine relaxes lymphatic vessels. Microcirculation. 2014 Oct;21(7):575-7. doi: 10.1111/micc.12162. PMID: 25123019; PMCID: PMC6859891.
Neumann J, Grobe JM, Weisgut J, Schwelberger HG, Fogel WA, Marušáková M, Wache H, Bähre H, Buchwalow IB, Dhein S, Hofmann B, Kirchhefer U, Gergs U. Histamine can be Formed and Degraded in the Human and Mouse Heart. Front Pharmacol. 2021 May 11;12:582916. doi: 10.3389/fphar.2021.582916. PMID: 34045955; PMCID: PMC8144513.
McNeill JH. Histamine and the heart. Can J Physiol Pharmacol. 1984 Jun;62(6):720-6. doi: 10.1139/y84-119. PMID: 6331617.
Hattori Y, Hattori K, Matsuda N. Regulation of the Cardiovascular System by Histamine. Handb Exp Pharmacol. 2017;241:239-258. doi: 10.1007/164_2016_15. PMID: 27838850.
Curtis MJ, Pugsley MK, Walker MJ. Endogenous chemical mediators of ventricular arrhythmias in ischaemic heart disease. Cardiovasc Res. 1993 May;27(5):703-19. doi: 10.1093/cvr/27.5.703. PMID: 8348568.

Adetle ilişkili yakınmnalar

Hamada, Y.; Shinohara, Y.; Yano, M.; Yamamoto, M.; Yoshio, M.; Satake, K.; Toda, A.; Hirai, M.; Usami, M. Effect of the menstrual cycle on serum diamine oxidase levels in healthy women. Clin. Biochem. 2013, 46, 99–102.
Pavlov V, Dimitrov O. Androgenic sensitivity of polyamine-oxidizing enzyme activities in female rat tissues. Amino Acids. 2000;18(4):399-405. doi: 10.1007/s007260070078. PMID: 10949922.

Hiperaktif mesane

Wang X, Liu W, O’Donnell M, Lutgendorf S, Bradley C, Schrepf A, Liu L, Kreder K, Luo Y. Evidence for the Role of Mast Cells in Cystitis-Associated Lower Urinary Tract Dysfunction: A Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network Animal Model Study. PLoS One. 2016 Dec 21;11(12):e0168772. doi: 10.1371/journal.pone.0168772. PMID: 28002455; PMCID: PMC5176179.
Wen C, Xie L, Hu C. Roles of mesenchymal stem cells and exosomes in interstitial cystitis/bladder pain syndrome. J Cell Mol Med. 2021 Dec 24. doi: 10.1111/jcmm.17132. Epub ahead of print. PMID: 34953040.
Lacour M. Betahistine treatment in managing vertigo and improving vestibular compensation: clarification. J Vestib Res. 2013;23(3):139-51. doi: 10.3233/VES-130496. PMID: 24177346.
Lv J, Huang Y, Zhu S, Yang G, Zhang Y, Leng J, Bo J, Liu D. MCP-1-induced histamine release from mast cells is associated with development of interstitial cystitis/bladder pain syndrome in rat models. Mediators Inflamm. 2012;2012:358184. doi: 10.1155/2012/358184. Epub 2012 Sep 19. PMID: 23049171; PMCID: PMC3459284.
Shan H, Zhang EW, Zhang P, Zhang XD, Zhang N, Du P, Yang Y. Differential expression of histamine receptors in the bladder wall tissues of patients with bladder pain syndrome/interstitial cystitis – significance in the responsiveness to antihistamine treatment and disease symptoms. BMC Urol. 2019 Nov 12;19(1):115. doi: 10.1186/s12894-019-0548-3. PMID: 31718622; PMCID: PMC6852726.
Keagy CD. The potential role of folate metabolism in interstitial cystitis. Int Urogynecol J. 2019 Mar;30(3):363-370. doi: 10.1007/s00192-018-3771-7. Epub 2018 Oct 6. PMID: 30293165.
Liu HT, Shie JH, Chen SH, Wang YS, Kuo HC. Differences in mast cell infiltration, E-cadherin, and zonula occludens-1 expression between patients with overactive bladder and interstitial cystitis/bladder pain syndrome. Urology. 2012 Jul;80(1):225.e13-8. doi: 10.1016/j.urology.2012.01.047. Epub 2012 Apr 21. PMID: 22521193.
Jhang JF, Jiang YH, Kuo HC. Current Understanding of the Pathophysiology and Novel Treatments of Interstitial Cystitis/Bladder Pain Syndrome. Biomedicines. 2022;10(10):2380. Published 2022 Sep 23. doi:10.3390/biomedicines10102380
Weinstock LB, Klutke CG, Lin HC. Small intestinal bacterial overgrowth in patients with interstitial cystitis and gastrointestinal symptoms. Dig Dis Sci. 2008 May;53(5):1246-51. doi: 10.1007/s10620-007-0022-z. Epub 2007 Oct 12. PMID: 17932763.
Stein P C, Torri A, Parsons C L. (1999) . Elevated urinary norepinephrine in interstitial cystitis.Urology53,1140–1143
Stromberga Z, Chess-Williams R, Moro C. (2019) Histamine modulation of urinary bladder urothelium, lamina propria and detrusor contractile activity via H1 and H2 receptors.Sci.Rep.9(1),3899
Jasmin L, Janni G, Ohara PT, Rabkin SD. CNS induced neurogenic cystitis is associated with bladder mast cell degranulation in the rat. J Urol. 2000 Sep;164(3 Pt 1):852-5. doi: 10.1097/00005392-200009010-00061. PMID: 10953167.

Histamin ve reseptörleri

Patel RH, Mohiuddin SS. Biochemistry, Histamine. [Updated 2021 May 9]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan-.
Moriguchi T, Takai J. Histamine and histidine decarboxylase: Immunomodulatory functions and regulatory mechanisms. Genes Cells. 2020 Jul;25(7):443-449. doi: 10.1111/gtc.12774. Epub 2020 May 12. PMID: 32394600; PMCID: PMC7497259.
Kjaer A, Knigge U, Rouleau A, Garbarg M, Warberg J. Dehydration-induced release of vasopressin involves activation of hypothalamic histaminergic neurons. Endocrinology. 1994 Aug;135(2):675-81. doi: 10.1210/endo.135.2.8033816. PMID: 8033816.
Brown RE, Stevens DR, Haas HL. The physiology of brain histamine. Prog Neurobiol. 2001 Apr;63(6):637-72. doi: 10.1016/s0301-0082(00)00039-3. PMID: 11164999.
Zhang M, Venable JD, Thurmond RL. The histamine H4 receptor in autoimmune disease. Expert Opin Investig Drugs. 2006 Nov;15(11):1443-52. doi: 10.1517/13543784.15.11.1443. PMID: 17040202.
E, Matilla MA. Histamine: A Bacterial Signal Molecule. Int J Mol Sci. 2021 Jun 12;22(12):6312. doi: 10.3390/ijms22126312. PMID: 34204625; PMCID: PMC8231116.
Carthy E, Ellender T. Histamine, Neuroinflammation and Neurodevelopment: A Review. Front Neurosci. 2021 Jul 14;15:680214. doi: 10.3389/fnins.2021.680214. PMID: 34335160; PMCID: PMC8317266.
Yamada, S., Guo, X., Wang, K.Y., et al., Novel function of histamine signaling via histamine receptors in cholesterol and bile acid metabolism: histamine H2 receptor protects against nonalcoholic fatty liver disease, Pathol. Int., 2016, vol. 66, no. 7, pp. 376—385.
Branco ACCC, Yoshikawa FSY, Pietrobon AJ, Sato MN. Role of Histamine in Modulating the Immune Response and Inflammation. Mediators Inflamm. 2018 Aug 27;2018:9524075. doi: 10.1155/2018/9524075. PMID: 30224900; PMCID: PMC6129797.

Histamini yıkan enzimler; DAO, HNMT ve diğer amin oksidazlar

Tan, Z.; Ou, Y.; Cai, W.; Zheng, Y.; Li, H.; Mao, Y.; Zhou, S.; Tu, J. Advances in the Clinical Application of Histamine and Diamine Oxidase (DAO) Activity: A Review. Catalysts 2023, 13, 48.
Mušič E, Korošec P, Šilar M, Adamič K, Košnik M, Rijavec M. Serum diamine oxidase activity as a diagnostic test for histamine intolerance. Wien Klin Wochenschr. 2013 May;125(9-10):239-43. doi: 10.1007/s00508-013-0354-y. Epub 2013 Apr 12. PMID: 23579881.
Yoshikawa T, Nakamura T, Yanai K. Histamine N-Methyltransferase in the Brain. Int J Mol Sci. 2019;20(3):737. Published 2019 Feb 10. doi:10.3390/ijms20030737
Lackner S, Malcher V, Enko D, Mangge H, Holasek SJ, Schnedl WJ. Histamine-reduced diet and increase of serum diamine oxidase correlating to diet compliance in histamine intolerance. Eur J Clin Nutr. 2019 Jan;73(1):102-104. doi: 10.1038/s41430-018-0260-5. Epub 2018 Jul 18. PMID: 30022117.
Soda K. Polyamine Metabolism and Gene Methylation in Conjunction with One-Carbon Metabolism. Int J Mol Sci. 2018;19(10):3106. Published 2018 Oct 10. doi:10.3390/ijms19103106
Laurino A, Landucci E, Raimondi L. Central Effects of 3-Iodothyronamine Reveal a Novel Role for Mitochondrial Monoamine Oxidases. Front Endocrinol (Lausanne). 2018 Jun 6;9:290. doi: 10.3389/fendo.2018.00290. PMID: 29928258; PMCID: PMC5998184
Shan L, Bao AM, Swaab DF. Changes in Histidine Decarboxylase, Histamine N-Methyltransferase and Histamine Receptors in Neuropsychiatric Disorders. Handb Exp Pharmacol. 2017;241:259-276. doi: 10.1007/164_2016_125. PMID: 28233178.
Manzotti G, Breda D, Di Gioacchino M, Burastero SE. Serum diamine oxidase activity in patients with histamine intolerance. Int J Immunopathol Pharmacol. 2016 Mar;29(1):105-11. doi: 10.1177/0394632015617170. Epub 2015 Nov 16. PMID: 26574488; PMCID: PMC5806734.
Enko D, Meinitzer A, Mangge H, Kriegshäuser G, Halwachs-Baumann G, Reininghaus EZ, Bengesser SA, Schnedl WJ. Concomitant Prevalence of Low Serum Diamine Oxidase Activity and Carbohydrate Malabsorption. Can J Gastroenterol Hepatol. 2016;2016:4893501. doi: 10.1155/2016/4893501. Epub 2016 Nov 30. PMID: 28042564; PMCID: PMC5155086.
Cucca, V.; Ramirez, G.A.; Pignatti, P.; Asperti, C.; Russo, M.; Della-Torre, E.; Breda, D.; Burastero, S.E.; Dagna, L.; Yacoub, M.-R. Basal Serum Diamine Oxidase Levels as a Biomarker of Histamine Intolerance: A Retrospective Cohort Study. Nutrients 2022, 14, 1513. https://doi.org/10.3390/nu14071513
Schnedl WJ, Meier-Allard N, Michaelis S, Lackner S, Enko D, Mangge H, Holasek SJ. Serum Diamine Oxidase Values, Indicating Histamine Intolerance, Influence Lactose Tolerance Breath Test Results. Nutrients. 2022 May 12;14(10):2026. doi: 10.3390/nu14102026. PMID: 35631167; PMCID: PMC9146026.
Neree AT, Soret R, Marcocci L, Pietrangeli P, Pilon N, Mateescu MA. Vegetal diamine oxidase alleviates histamine-induced contraction of colonic muscles. Sci Rep. 2020 Dec 9;10(1):21563. doi: 10.1038/s41598-020-78134-3. PMID: 33299054; PMCID: PMC7726047.
Jumarie C., Séïde M., Marcocci L., Pietrangeli P., Mateescu M.A. Diamine oxidase from white pea (Lathyrus sativus) combined with catalase protects the human intestinal Caco-2 cell line from histamine damage. Appl. Biochem. Biotechnol. 2017;182:1171–1181. doi: 10.1007/s12010-016-2390-3.
Ji Y., Sakata Y., Li X., Zhang C., Yang Q., Xu M., Wollin A., Langhans W., Tso P. Lymphatic diamine oxidase secretion stimulated by fat absorption is linked with histamine release. Am. J. Physiol. Gastrointest. Liver Physiol. 2013;304:G732–G740. doi: 10.1152/ajpgi.00399.2012.

Histamin intoleransı genetik bir hastalık mı?

Szczepankiewicz A, Bręborowicz A, Sobkowiak P, Popiel A. Polymorphisms of two histamine-metabolizing enzymes genes and childhood allergic asthma: a case control study. Clin Mol Allergy. 2010 Nov 1;8:14. doi: 10.1186/1476-7961-8-14. PMID: 21040557; PMCID: PMC2990726.
García-Martín E, García-Menaya J, Sánchez B, Martínez C, Rosendo R, Agúndez JA. Polymorphisms of histamine-metabolizing enzymes and clinical manifestations of asthma and allergic rhinitis. Clin Exp Allergy. 2007 Aug;37(8):1175-82. doi: 10.1111/j.1365-2222.2007.02769.x. PMID: 17651147.
Maintz L, Yu CF, Rodríguez E, Baurecht H, Bieber T, Illig T, Weidinger S, Novak N. Association of single nucleotide polymorphisms in the diamine oxidase gene with diamine oxidase serum activities. Allergy. 2011 Jul;66(7):893-902. doi: 10.1111/j.1398-9995.2011.02548.x. Epub 2011 Apr 13. PMID: 21488903.
Ayuso P, García-Martín E, Martínez C, Agúndez JA. Genetic variability of human diamine oxidase: occurrence of three nonsynonymous polymorphisms and study of their effect on serum enzyme activity. Pharmacogenet Genomics. 2007 Sep;17(9):687-93. doi: 10.1097/FPC.0b013e328012b8e4. PMID: 17700358
Kucher A.N. Association of polymorphic variants of key histamine metabolism genes and histamine receptor genes with multifactorial diseases. Russ. J. Genet. 2019;55:794–814. doi: 10.1134/S102279541907010X.
Agúndez JA, Ayuso P, Cornejo-García JA, Blanca M, Torres MJ, Doña I, Salas M, Blanca-López N, Canto G, Rondon C, Campo P, Laguna JJ, Fernández J, Martínez C, García-Martín E. The diamine oxidase gene is associated with hypersensitivity response to non-steroidal anti-inflammatory drugs. PLoS One. 2012;7(11):e47571. doi: 10.1371/journal.pone.0047571. Epub 2012 Nov 12. PMID: 23152756; PMCID: PMC3495953.

Diğer biyojenik aminler

Sánchez-Pérez S, Comas-Basté O, Veciana-Nogués MT, Latorre-Moratalla ML, Vidal-Carou MC. Low-Histamine Diets: Is the Exclusion of Foods Justified by Their Histamine Content? Nutrients. 2021 Apr 21;13(5):1395. doi: 10.3390/nu13051395. PMID: 33919293; PMCID: PMC8143338.
Sánchez-Pérez S, Comas-Basté O, Rabell-González J, Veciana-Nogués MT, Latorre-Moratalla ML, Vidal-Carou MC. Biogenic Amines in Plant-Origin Foods: Are They Frequently Underestimated in Low-Histamine Diets? Foods. 2018 Dec 14;7(12):205. doi: 10.3390/foods7120205. PMID: 30558197; PMCID: PMC6306728.
Hernández-Macias S, Martín-Garcia A, Ferrer-Bustins N, et al. Inhibition of Biogenic Amines Formation in Fermented Foods by the Addition of Cava Lees. Front Microbiol. 2022;12:818565. Published 2022 Jan 28. doi:10.3389/fmicb.2021.818565
Biji KB, Ravishankar CN, Venkateswarlu R, Mohan CO, Gopal TK. Biogenic amines in seafood: a review. J Food Sci Technol. 2016;53(5):2210-2218. doi:10.1007/s13197-016-2224-x
Stratton JE, Hutkins RW, Taylor SL. Biogenic Amines in Cheese and other Fermented Foods: A Review. J Food Prot. 1991 Jun;54(6):460-470. doi: 10.4315/0362-028X-54.6.460. PMID: 31051616.
Durak-Dados A, Michalski M, Osek J. Histamine and Other Biogenic Amines in Food. J Vet Res. 2020;64(2):281-288. Published 2020 Apr 30. doi:10.2478/jvetres-2020-0029
Doeun D, Davaatseren M, Chung MS. Biogenic amines in foods. Food Sci Biotechnol. 2017;26(6):1463-1474. Published 2017 Dec 13. doi:10.1007/s10068-017-0239-3
Fatih Ozcelik, Muhammed Cihan Temel, İlbey Kayra Ozcelik, Ebru Kale (2020) The Role of Biogenic Amines in Nutrition Toxicology: Review. International Journal of Nutrition – 5(1):21-29.

Bağırsaklar, bağışıklık sistemi ve artmış bağırsak geçirgenliği

Schnedl WJ, Enko D. Histamine Intolerance Originates in the Gut. Nutrients. 2021 Apr 12;13(4):1262. doi: 10.3390/nu13041262. PMID: 33921522; PMCID: PMC8069563.
Parrish A, Boudaud M, Kuehn A, Ollert M, Desai MS. Intestinal mucus barrier: a missing piece of the puzzle in food allergy. Trends Mol Med. 2022 Jan;28(1):36-50. doi: 10.1016/j.molmed.2021.10.004. Epub 2021 Nov 19. PMID: 34810087.
Yashiro T, Ogata H, Zaidi SF, Lee J, Hayashi S, Yamamoto T, Kadowaki M. Pathophysiological Roles of Neuro-Immune Interactions between Enteric Neurons and Mucosal Mast Cells in the Gut of Food Allergy Mice. Cells. 2021 Jun 23;10(7):1586. doi: 10.3390/cells10071586. PMID: 34201851; PMCID: PMC8305700.
Miglietta S, Borghini R, Relucenti M, Sorrentino V, Chen R, Li X, Fazi F, Donato G, Familiari G, Petrozza V, Picarelli A. New Insights into Intestinal Permeability in Irritable Bowel Syndrome-Like Disorders: Histological and Ultrastructural Findings of Duodenal Biopsies. Cells. 2021 Sep 29;10(10):2593. doi: 10.3390/cells10102593. PMID: 34685576; PMCID: PMC8533783.
Bassotti G, Villanacci V, Nascimbeni R, Cadei M, Manenti S, Sabatino G, Maurer CA, Cathomas G, Salerni B. Colonic mast cells in controls and slow transit constipation patients. Aliment Pharmacol Ther. 2011 Jul;34(1):92-9. doi: 10.1111/j.1365-2036.2011.04684.x. Epub 2011 May 3. PMID: 21539589.
Penissi AB, Rudolph MI, Piezzi RS. Role of mast cells in gastrointestinal mucosal defense. Biocell. 2003 Aug;27(2):163-72. PMID: 14510234.
Allam-Ndoul B, Castonguay-Paradis S, Veilleux A. Gut Microbiota and Intestinal Trans-Epithelial Permeability. Int J Mol Sci. 2020 Sep 3;21(17):6402. doi: 10.3390/ijms21176402. PMID: 32899147; PMCID: PMC7503654.
Montemurro P, Nishioka H, Dundon WG, de Bernard M, Del Giudice G, Rappuoli R, Montecucco C. The neutrophil-activating protein (HP-NAP) of Helicobacter pylori is a potent stimulant of mast cells. Eur J Immunol. 2002 Mar;32(3):671-6. doi: 10.1002/1521-4141(200203)32:3<671::aid-immu671>3.3.co;2-x. PMID: 11857341.
Keles N, Yavuz Arican R, Coskun M, Elpek GO. Histamine induces the neuronal hypertrophy and increases the mast cell density in gastrointestinal tract. Exp Toxicol Pathol. 2012 Nov;64(7-8):713-6. doi: 10.1016/j.etp.2011.01.005. Epub 2011 Feb 11. PMID: 21316206.
Samadi N, Klems M, Untersmayr E. The role of gastrointestinal permeability in food allergy. Ann Allergy Asthma Immunol. 2018 Aug;121(2):168-173. doi: 10.1016/j.anai.2018.05.010. Epub 2018 May 25. PMID: 29803708.
Smolinska S, Winiarska E, Globinska A, Jutel M. Histamine: A Mediator of Intestinal Disorders-A Review. Metabolites. 2022 Sep 23;12(10):895. doi: 10.3390/metabo12100895. PMID: 36295796; PMCID: PMC9610630.
Kuefner MA, Schwelberger HG, Weidenhiller M, Hahn EG, Raithel M. Both catabolic pathways of histamine via histamine-N-methyltransferase and diamine oxidase are diminished in the colonic mucosa of patients with food allergy. Inflamm Res. 2004 Mar;53 Suppl 1:S31-2. doi: 10.1007/s00011-003-0314-5. Epub 2004 Mar 5. PMID: 15054605.
Albenberg LG, Wu GD. Diet and the intestinal microbiome: associations, functions, and implications for health and disease. Gastroenterology. 2014;146(6):1564-1572. doi:10.1053/j.gastro.2014.01.058
Gurtner, A., Gonzalez-Perez, I. & Arnold, I.C. Intestinal eosinophils, homeostasis and response to bacterial intrusion. Semin Immunopathol 43, 295–306 (2021). https://doi.org/10.1007/s00281-021-00856-x
Rohrhofer J, Zwirzitz B, Selberherr E, Untersmayr E. The Impact of Dietary Sphingolipids on Intestinal Microbiota and Gastrointestinal Immune Homeostasis. Front Immunol. 2021 May 14;12:635704. doi: 10.3389/fimmu.2021.635704. PMID: 34054805; PMCID: PMC8160510.
Zhang X, Borbet TC, Fallegger A, Wipperman MF, Blaser MJ, Müller A. An Antibiotic-Impacted Microbiota Compromises the Development of Colonic Regulatory T Cells and Predisposes to Dysregulated Immune Responses. mBio. 2021 Feb 2;12(1):e03335-20. doi: 10.1128/mBio.03335-20. PMID: 33531385; PMCID: PMC7858066.
Marshall JS, Portales-Cervantes L, Leong E. Mast Cell Responses to Viruses and Pathogen Products. Int J Mol Sci. 2019;20(17):4241. Published 2019 Aug 30. doi:10.3390/ijms20174241
Serek, P.; Oleksy-Wawrzyniak, M. The Effect of Bacterial Infections, Probiotics and Zonulin on Intestinal Barrier Integrity. Int. J. Mol. Sci. 2021, 22, 11359. https://doi.org/10.3390/ijms222111359
Wesemann DR, Nagler CR. The Microbiome, Timing, and Barrier Function in the Context of Allergic Disease. Immunity. 2016 Apr 19;44(4):728-38. doi: 10.1016/j.immuni.2016.02.002. PMID: 27096316; PMCID: PMC4869964.

Atopi, Tip I alerjiler ve anafilaksi

Wagner A, Buczyłko K, Zielińska-Bliźniewska H, Wagner W. Impaired resolution of wheals in the skin prick test and low diamine oxidase blood level in allergic patients. Postepy Dermatol Alergol. 2019;36(5):538-543. doi:10.5114/ada.2019.89504
Justiz Vaillant AA, Vashisht R, Zito PM. Immediate Hypersensitivity Reactions. 2021 Jun 11. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan–. PMID: 30020687.
Ohsawa Y, Hirasawa N. The role of histamine H1 and H4 receptors in atopic dermatitis: from basic research to clinical study. Allergol Int. 2014 Dec;63(4):533-42. doi: 10.2332/allergolint.13-RA-0675. PMID: 25249063.
Maintz L, Benfadal S, Allam JP, Hagemann T, Fimmers R, Novak N. Evidence for a reduced histamine degradation capacity in a subgroup of patients with atopic eczema. J Allergy Clin Immunol. 2006 May;117(5):1106-12. doi: 10.1016/j.jaci.2005.11.041. Epub 2006 Feb 8. PMID: 16675339.
Worm M, Fiedler EM, Dölle S, Schink T, Hemmer W, Jarisch R, Zuberbier T. Exogenous histamine aggravates eczema in a subgroup of patients with atopic dermatitis. Acta Derm Venereol. 2009;89(1):52-6. doi: 10.2340/00015555-0565. PMID: 19197542.
Undem BJ, Taylor-Clark T. Mechanisms underlying the neuronal-based symptoms of allergy. J Allergy Clin Immunol. 2014 Jun;133(6):1521-34. doi: 10.1016/j.jaci.2013.11.027. Epub 2014 Jan 13. PMID: 24433703; PMCID: PMC6483074.
Olbrich CL, Bivas-Benita M, Xenakis JJ, Maldonado S, Cornwell E, Fink J, Yuan Q, Gill N, Mansfield R, Dockstader K, Spencer LA. Remote allergen exposure elicits eosinophil infiltration into allergen nonexposed mucosal organs and primes for allergic inflammation. Mucosal Immunol. 2020 Sep;13(5):777-787. doi: 10.1038/s41385-020-0310-x. Epub 2020 Jun 9. PMID: 32518365; PMCID: PMC7442625.
Macy E. Practical Management of New-Onset Urticaria and Angioedema Presenting in Primary Care, Urgent Care, and the Emergency Department. Perm J. 2021;25:21.058. Published 2021 Nov 22. doi:10.7812/TPP/21.058
Wagner A, Buczyłko K, Zielińska-Bliźniewska H, Wagner W. Impaired resolution of wheals in the skin prick test and low diamine oxidase blood level in allergic patients. Postepy Dermatol Alergol. 2019 Oct;36(5):538-543. doi: 10.5114/ada.2019.89504. Epub 2019 Nov 12. PMID: 31839770; PMCID: PMC6906969.

Mast hücreleri / Mast hücresi aktivasyon sendromu (MCAS)

Kim HS, Kawakami Y, Kasakura K, Kawakami T. Recent advances in mast cell activation and regulation. F1000Res. 2020 Mar 19;9:F1000 Faculty Rev-196. doi: 10.12688/f1000research.22037.1. PMID: 32226609; PMCID: PMC7096214.
Akin C, Valent P, Metcalfe DD. Mast cell activation syndrome: Proposed diagnostic criteria. J Allergy Clin Immunol. 2010;126(6):1099-104.e4. doi:10.1016/j.jaci.2010.08.035
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Theoharides TC, Tsilioni I, Ren H. Recent advances in our understanding of mast cell activation – or should it be mast cell mediator disorders?. Expert Rev Clin Immunol. 2019;15(6):639-656. doi:10.1080/1744666X.2019.1596800
Kleij HP, Bienenstock J. Significance of Conversation between Mast Cells and Nerves. Allergy Asthma Clin Immunol. 2005 Jun 15;1(2):65-80. doi: 10.1186/1710-1492-1-2-65. Epub 2005 Jun 15. PMID: 20529227; PMCID: PMC2877069.
Boehm T, Reiter B, Ristl R, et al. Massive release of the histamine-degrading enzyme diamine oxidase during severe anaphylaxis in mastocytosis patients. Allergy. 2019;74(3):583-593. doi:10.1111/all.13663
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Ramsay DB, Stephen S, Borum M, Voltaggio L, Doman DB. Mast cells in gastrointestinal disease. Gastroenterol Hepatol (N Y). 2010;6(12):772-777.
Afrin LB. Some cases of hypermobile Ehlers-Danlos syndrome may be rooted in mast cell activation syndrome. Am J Med Genet C Semin Med Genet. 2021 Dec;187(4):466-472. doi: 10.1002/ajmg.c.31944. Epub 2021 Oct 31. PMID: 34719842.
Brock I, Prendergast W, Maitland A. Mast cell activation disease and immunoglobulin deficiency in patients with hypermobile Ehlers-Danlos syndrome/hypermobility spectrum disorder. Am J Med Genet C Semin Med Genet. 2021 Dec;187(4):473-481. doi: 10.1002/ajmg.c.31940. Epub 2021 Nov 7. PMID: 34747107.
Bonamichi-Santos R, Yoshimi-Kanamori K, Giavina-Bianchi P, Aun MV. Association of Postural Tachycardia Syndrome and Ehlers-Danlos Syndrome with Mast Cell Activation Disorders. Immunol Allergy Clin North Am. 2018 Aug;38(3):497-504. doi: 10.1016/j.iac.2018.04.004. Epub 2018 Jun 9. PMID: 30007466.
Cimolai N. Comparing histamine intolerance and non-clonal mast cell activation syndrome. Intest Res. 2020 Jan;18(1):134-135. doi: 10.5217/ir.2019.00087. Epub 2020 Jan 30. PMID: 32013319; PMCID: PMC7000637.
Wypasek E, Natorska J, Stankiewicz E, Kolaczkowska E. Morphine-modulated mast cell migration and proliferation during early stages of zymosan-induced peritonitis in CBA mice. Folia Biol (Krakow). 2011;59(3-4):99-106. doi: 10.3409/fb59_3-4.99-106. PMID: 22195461.
Leon A, Buriani A, Dal Toso R, Fabris M, Romanello S, Aloe L, Levi-Montalcini R. Mast cells synthesize, store, and release nerve growth factor. Proc Natl Acad Sci U S A. 1994 Apr 26;91(9):3739-43. doi: 10.1073/pnas.91.9.3739. PMID: 8170980; PMCID: PMC43657.
Matito A, Escribese MM, Longo N, et al. Clinical approach to mast cell activation syndromes: a practical overview. J Investig Allergol Clin Immunol. 2021;31(6).
Parsons IT, Stacey MJ, Faconti L, Hill N, O’Hara J, Walter E, Farukh B, McNally R, Sharp H, Patten A, Grimaldi R, Gall N, Chowienczyk P, Woods DR. Histamine, mast cell tryptase and post-exercise hypotension in healthy and collapsed marathon runners. Eur J Appl Physiol. 2021 May;121(5):1451-1459. doi: 10.1007/s00421-021-04645-0. Epub 2021 Feb 24. Erratum in: Eur J Appl Physiol. 2021 Nov;121(11):3257-3258. PMID: 33629149; PMCID: PMC8373737.
Aldan JT, Jansen C, Speck M, Maaetoft-Udsen K, Cordasco EA, Faiai M, Shimoda LMN, Greineisen WE, Turner H, Stokes AJ. Insulin-induced lipid body accumulation is accompanied by lipid remodelling in model mast cells. Adipocyte. 2019 Dec;8(1):265-279. doi: 10.1080/21623945.2019.1636624. PMID: 31311389; PMCID: PMC6768188.
Wang HC, Huang SK. Metformin inhibits IgE- and aryl hydrocarbon receptor-mediated mast cell activation in vitro and in vivo. Eur J Immunol. 2018 Dec;48(12):1989-1996. doi: 10.1002/eji.201847706. Epub 2018 Oct 25. PMID: 30242842.
Kakavas S, Karayiannis D, Mastora Z. The Complex Interplay between Immunonutrition, Mast Cells, and Histamine Signaling in COVID-19. Nutrients. 2021 Sep 29;13(10):3458. doi: 10.3390/nu13103458. PMID: 34684460; PMCID: PMC8537261.
Barrea L, Verde L, Grant WB, Frias-Toral E, Sarno G, Vetrani C, Ceriani F, Garcia-Velasquez E, Contreras-Briceño J, Savastano S, Colao A, Muscogiuri G. Vitamin D: A Role Also in Long COVID-19? Nutrients. 2022 Apr 13;14(8):1625. doi: 10.3390/nu14081625. PMID: 35458189; PMCID: PMC9028162.
Obara I, Fernandes JPS, Tiligada E. Histamine research advancements in the second year of the COVID-19 pandemic: report of the European Histamine Research Society (EHRS). Inflamm Res. 2022 Aug;71(7-8):995-998. doi: 10.1007/s00011-022-01589-9. Epub 2022 Jun 1. PMID: 35648157; PMCID: PMC9158306.
da Silveira Gorman R, Syed IU. Connecting the Dots in Emerging Mast Cell Research: Do Factors Affecting Mast Cell Activation Provide a Missing Link between Adverse COVID-19 Outcomes and the Social Determinants of Health? Med Sci (Basel). 2022 May 28;10(2):29. doi: 10.3390/medsci10020029. PMID: 35736349; PMCID: PMC9228930.
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Kedor C, Freitag H, Meyer-Arndt L, Wittke K, Hanitsch LG, Zoller T, Steinbeis F, Haffke M, Rudolf G, Heidecker B, Bobbert T, Spranger J, Volk HD, Skurk C, Konietschke F, Paul F, Behrends U, Bellmann-Strobl J, Scheibenbogen C. A prospective observational study of post-COVID-19 chronic fatigue syndrome following the first pandemic wave in Germany and biomarkers associated with symptom severity. Nat Commun. 2022 Aug 30;13(1):5104. doi: 10.1038/s41467-022-32507-6. PMID: 36042189; PMCID: PMC9426365.
Johansson M, Ståhlberg M, Runold M, Nygren-Bonnier M, Nilsson J, Olshansky B, Bruchfeld J, Fedorowski A. Long-Haul Post-COVID-19 Symptoms Presenting as a Variant of Postural Orthostatic Tachycardia Syndrome: The Swedish Experience. JACC Case Rep. 2021 Apr;3(4):573-580. doi: 10.1016/j.jaccas.2021.01.009. Epub 2021 Mar 10. PMID: 33723532; PMCID: PMC7946344.
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Matito A, Escribese MM, Longo N, Mayorga C, Luengo-Sánchez O, Pérez-Gordo M, Matheu V, Labrador-Horrillo M, Pascal M, Seoane-Reula ME; Comité de Inmunología de la Sociedad Española de Alergología e Inmunología Clínica (SEAIC). Clinical Approach to Mast Cell Activation Syndrome: A Practical Overview. J Investig Allergol Clin Immunol. 2021 Dec 21;31(6):461-470. doi: 10.18176/jiaci.0675. Epub 2020 Feb 5. PMID: 33541851.
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İçerideki ve dışarıdaki bakteriler

Shi L, Li Y, Liu Y, Jia H. Alterations of gut microbiota and cytokines in elevated serum diamine oxidase disorder. Medicine (Baltimore). 2022 Dec 16;101(50):e31966. doi: 10.1097/MD.0000000000031966. PMID: 36550793; PMCID: PMC9771309.
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Kim SH, Field KG, Morrissey MT, Price RJ, Wei CI, An H. Source and identification of histamine-producing bacteria from fresh and temperature-abused albacore. J Food Prot. 2001 Jul;64(7):1035-44. doi: 10.4315/0362-028x-64.7.1035. PMID: 11456189.
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Prebiyotik, probiyotik, simbiyotik ve postbiyotikler

Duan C, Ma L, Yu J, Sun Y, Liu L, Ma F, Li X, Li D. Oral administration of Lactobacillus plantarum JC7 alleviates OVA-induced murine food allergy through immunoregulation and restoring disordered intestinal microbiota. Eur J Nutr. 2022 Oct 4:1–14. doi: 10.1007/s00394-022-03016-5. Epub ahead of print. PMID: 36194269; PMCID: PMC9530419.
Thorakkattu, P., Khanashyam, A. C., Shah, K., Babu, K. S., Mundanat, A. S., Deliephan, A., … & Nirmal, N. P. (2022). Postbiotics: Current trends in food and Pharmaceutical industry. Foods, 11(19), 3094.

Kısa zincirli yağ asitleri

Ramos Meyers G, Samouda H, Bohn T. Short Chain Fatty Acid Metabolism in Relation to Gut Microbiota and Genetic Variability. Nutrients. 2022 Dec 16;14(24):5361. doi: 10.3390/nu14245361. PMID: 36558520; PMCID: PMC9788597.
Kim, C.H. Control of lymphocyte functions by gut microbiota-derived short-chain fatty acids. Cell Mol Immunol 18, 1161–1171 (2021).

Mayalar ve küf mantarları

Schulze J, Sonnenborn U. Yeasts in the gut: from commensals to infectious agents. Dtsch Arztebl Int. 2009;106(51-52):837-842. doi:10.3238/arztebl.2009.0837
Jang H, Lee GW, Kim YH, Min J. Histamine binding activity of surface-modified yeast by histamine binding protein (HBP). AMB Express. 2021 Oct 29;11(1):146. doi: 10.1186/s13568-021-01308-3. PMID: 34716508; PMCID: PMC8556473.
Kritas SK, Gallenga CE, D Ovidio C, Ronconi G, Caraffa Al, Toniato E, Lauritano D, Conti P. Impact of mold on mast cell-cytokine immune response. J Biol Regul Homeost Agents. 2018 Jul-Aug;32(4):763-768. PMID: 30043558.
Conti P, Tettamanti L, Mastrangelo F, Ronconi G, Frydas I, Kritas SK, Caraffa A, Pandolfi F. Impact of Fungi on Immune Responses. Clin Ther. 2018 Jun;40(6):885-888. doi: 10.1016/j.clinthera.2018.04.010. Epub 2018 May 8. PMID: 29752039.
Kraft S, Buchenauer L, Polte T. Mold, Mycotoxins and a Dysregulated Immune System: A Combination of Concern?. Int J Mol Sci. 2021;22(22):12269. Published 2021 Nov 12. doi:10.3390/ijms222212269
Dinis-Oliveira, R.J. The Auto-Brewery Syndrome: A Perfect Metabolic “Storm” with Clinical and Forensic Implications. J. Clin. Med. 2021, 10, 4637. https://doi.org/10.3390/jcm10204637
Fresko I, Ugurlu S, Ozbakir F, et al. (2005). “Anti-Saccharomyces cerevisiae antibodies (ASCA) in Behçet’s syndrome”. Clin. Exp. Rheumatol. 23 (4 Suppl 38): S67–70. PMID 16273768.

Vagus siniri

Xu H, Shi X, Li X, et al. Neurotransmitter and neuropeptide regulation of mast cell function: a systematic review. J Neuroinflammation. 2020;17(1):356. Published 2020 Nov 25. doi:10.1186/s12974-020-02029-3
Forsythe P. The parasympathetic nervous system as a regulator of mast cell function. Methods Mol Biol. 2015;1220:141-54. doi: 10.1007/978-1-4939-1568-2_9. PMID: 25388249.

Besin duyarlılıkları

Pfanzagl B, Zevallos VF, Schuppan D, Pfragner R, Jensen-Jarolim E. Histamine causes influx via T-type voltage-gated calcium channels in an enterochromaffin tumor cell line: potential therapeutic target in adverse food reactions. Am J Physiol Gastrointest Liver Physiol. 2019 Feb 1;316(2):G291-G303. doi: 10.1152/ajpgi.00261.2018. Epub 2018 Dec 12. PMID: 30540489.
Tuck CJ, Biesiekierski JR, Schmid-Grendelmeier P, Pohl D. Food Intolerances. Nutrients. 2019;11(7):1684. Published 2019 Jul 22.
Lozano-Ojalvo D, Berin C, Tordesillas L. Immune Basis of Allergic Reactions to Food. J Investig Allergol Clin Immunol. 2019;29(1):1-14. doi: 10.18176/jiaci.0355. Epub 2018 Nov 20. PMID: 30457106.
Zopf Y, Baenkler HW, Silbermann A, Hahn EG, Raithel M. The differential diagnosis of food intolerance. Dtsch Arztebl Int. 2009;106(21):359-370. doi:10.3238/arztebl.2009.0359
Dieterich W, Tietz E, Kohl M, Konturek PC, Rath T, Neurath MF, Zopf Y. Food Intolerance of Unknown Origin: Caused by Mucosal Inflammation? A Pilot Study. Clin Transl Gastroenterol. 2021 Feb 17;12(2):e00312. doi: 10.14309/ctg.0000000000000312. PMID: 33600102; PMCID: PMC7889373
Krstić Ristivojević M, Apostolović D, Smiljanić K. Enterocytes in Food Hypersensitivity Reactions. Animals (Basel). 2021 Sep 17;11(9):2713. doi: 10.3390/ani11092713. PMID: 34573679; PMCID: PMC8466009.
Gargano, D.; Appanna, R.; Santonicola, A.; De Bartolomeis, F.; Stellato, C.; Cianferoni, A.; Casolaro, V.; Iovino, P. Food Allergy and Intolerance: A Narrative Review on Nutritional Concerns. Nutrients 2021, 13, 1638. https://doi.org/10.3390/nu13051638
Aguilera-Lizarraga, J., Florens, M.V., Viola, M.F. et al. Local immune response to food antigens drives meal-induced abdominal pain. Nature 590, 151–156 (2021). https://doi.org/10.1038/s41586-020-03118-2

Besin alerjileri

Calvani M, Anania C, Caffarelli C, Martelli A, Miraglia Del Giudice M, Cravidi C, Duse M, Manti S, Tosca MA, Cardinale F, Chiappini E, Olivero F, Marseglia GL. Food allergy: an updated review on pathogenesis, diagnosis, prevention and management. Acta Biomed. 2020 Sep 15;91(11-S):e2020012. doi: 10.23750/abm.v91i11-S.10316. PMID: 33004782; PMCID: PMC8023067.
Goldberg MR, Mor H, Magid Neriya D, Magzal F, Muller E, Appel MY, Nachshon L, Borenstein E, Tamir S, Louzoun Y, Youngster I, Elizur A, Koren O. Microbial signature in IgE-mediated food allergies. Genome Med. 2020 Oct 27;12(1):92. doi: 10.1186/s13073-020-00789-4. PMID: 33109272; PMCID: PMC7592384.
Raithel, M., Hagel, A., Albrecht, H. et al. Excretion of urinary histamine and N-tele methylhistamine in patients with gastrointestinal food allergy compared to non-allergic controls during an unrestricted diet and a hypoallergenic diet. BMC Gastroenterol 15, 41 (2015).
Moriyama T. Diversity of Food Allergy. J Nutr Sci Vitaminol (Tokyo). 2015;61 Suppl:S106-8. doi: 10.3177/jnsv.61.S106. PMID: 26598816.
Myszkowska D, Zapała B, Bulanda M, Czarnobilska E. Non-IgE Mediated Hypersensitivity to Food Products or Food Intolerance-Problems of Appropriate Diagnostics. Medicina (Kaunas). 2021 Nov 14;57(11):1245. doi: 10.3390/medicina57111245. PMID: 34833463; PMCID: PMC8625578.
De Martinis M, Sirufo MM, Viscido A, Ginaldi L. Food Allergies and Ageing. Int J Mol Sci. 2019 Nov 8;20(22):5580. doi: 10.3390/ijms20225580. PMID: 31717303; PMCID: PMC6888073.
Koenig JFE, Bruton K, Phelps A, Grydziuszko E, Jiménez-Saiz R, Jordana M. Memory Generation and Re-Activation in Food Allergy. Immunotargets Ther. 2021;10:171-184. Published 2021 Jun 9. doi:10.2147/ITT.S284823
Cañas, J.A.; Núñez, R.; Cruz-Amaya, A.; Gómez, F.; Torres, M.J.; Palomares, F.; Mayorga, C. Epigenetics in Food Allergy and Immunomodulation. Nutrients 2021, 13, 4345. https://doi.org/10.3390/nu13124345
Chen T, Liu X, Ma L, He W, Li W, Cao Y, Liu Z. Food allergens affect the intestinal tight junction permeability in inducing intestinal food allergy in rats. Asian Pac J Allergy Immunol. 2014 Dec;32(4):345-53. doi: 10.12932/AP0443.32.4.2014. PMID: 25543046.
Nocerino, R.; Pezzella, V.; Cosenza, L.; Amoroso, A.; Di Scala, C.; Amato, F.; Iacono, G.; Canani, R.B. The Controversial Role of Food Allergy in Infantile Colic: Evidence and Clinical Management. Nutrients2015, 7, 2015-2025.
Campbell, E., Hesser, L.A. & Nagler, C.R. B cells and the microbiota: a missing connection in food allergy. Mucosal Immunol 14, 4–13 (2021). https://doi.org/10.1038/s41385-020-00350-x
Sikorska-Szaflik, Hanna, and Barbara Sozańska. “Primary prevention of food allergy—Environmental protection beyond diet.” Nutrients 13.6 (2021): 2025.
Łoś-Rycharska, E.; Gołębiewski, M.; Sikora, M.; Grzybowski, T.; Gorzkiewicz, M.; Popielarz, M.; Gawryjołek, J.; Krogulska, A. A Combined Analysis of Gut and Skin Microbiota in Infants with Food Allergy and Atopic Dermatitis: A Pilot Study. Nutrients 2021, 13, 1682. https://doi.org/10.3390/nu13051682
Gu Y, Yao L, Jiang T, Che H. The Interaction of Food Allergy and Diabetes: Food Allergy Effects on Diabetic Mice by Intestinal Barrier Destruction and Glucagon-like Peptide 1 Reduction in Jejunum. Foods. 2022 Nov 22;11(23):3758. doi: 10.3390/foods11233758. PMID: 36496564; PMCID: PMC9741085.
Stapel SO, Asero R, Ballmer-Weber BK, Knol EF, Strobel S, Vieths S, Kleine-Tebbe J; EAACI Task Force. Testing for IgG4 against foods is not recommended as a diagnostic tool: EAACI Task Force Report. Allergy. 2008 Jul;63(7):793-6. doi: 10.1111/j.1398-9995.2008.01705.x. Epub 2008 May 16. PMID: 18489614.

Polen Besin alerjisi sendromu

Alessandri C, Ferrara R, Bernardi ML, et al. Molecular approach to a patient’s tailored diagnosis of the oral allergy syndrome. Clin Transl Allergy. 2020;10:22. Published 2020 Jun 17. doi:10.1186/s13601-020-00329-8

IgE aracılı olmayan besin alerjileri

Kaya A, Toyran M, Civelek E, Misirlioglu E, Kirsaclioglu C, Kocabas CN. Characteristics and Prognosis of Allergic Proctocolitis in Infants. J Pediatr Gastroenterol Nutr. 2015 Jul;61(1):69-73. doi: 10.1097/MPG.0000000000000767. PMID: 26039942.
Beşer OF, Sancak S, Erkan T, Kutlu T, Cokuğraş H, Cokuğraş FÇ. Can Fecal Calprotectin Level Be Used as a Markers of Inflammation in the Diagnosis and Follow-Up of Cow’s Milk Protein Allergy? Allergy Asthma Immunol Res. 2014 Jan;6(1):33-8. doi: 10.4168/aair.2014.6.1.33. Epub 2013 Nov 8. PMID: 24404391; PMCID: PMC3881398.
Roca, M.; Donat, E.; Rodriguez Varela, A.; Carvajal, E.; Cano, F.; Armisen, A.; Ekoff, H.; Cañada-Martínez, A.J.; Rydell, N.; Ribes-Koninckx, C. Fecal Calprotectin and Eosinophil-Derived Neurotoxin in Children with Non-IgE-Mediated Cow’s Milk Protein Allergy. J. Clin. Med. 2021, 10, 1595.

Eozinofilik özofajit ve diğer eozinofilik sindirim sistemi hastalıkları

Zhernov YV, Vysochanskaya SO, Sukhov VA, Zaostrovtseva OK, Gorshenin DS, Sidorova EA, Mitrokhin OV. Molecular Mechanisms of Eosinophilic Esophagitis. Int J Mol Sci. 2021 Dec 7;22(24):13183. doi: 10.3390/ijms222413183. PMID: 34947981; PMCID: PMC8703627.
804811.
Sunkara T, Rawla P, Yarlagadda KS, Gaduputi V. Eosinophilic gastroenteritis: diagnosis and clinical perspectives. Clin Exp Gastroenterol. 2019 Jun 5;12:239-253. doi: 10.2147/CEG.S173130. PMID: 31239747; PMCID: PMC6556468.

Besinlere bağlı egzersiz ile indüklenen anafilaksi

Minty B. Food-dependent exercise-induced anaphylaxis. Can Fam Physician. 2017;63(1):42-43.
Morita E, Kunie K, Matsuo H. Food-dependent exercise-induced anaphylaxis. J Dermatol Sci. 2007 Aug;47(2):109-17. doi: 10.1016/j.jdermsci.2007.03.004. Epub 2007 May 15. PMID: 17507204.

Yaşlılarda besin alerjileri

Alfa-gal alerjisi

Keleş Ş, Gündüz M. Alpha gal specific IgE positivity due to tick bites and red meat allergy: the first case report in Turkey. Turk J Pediatr. 2019;61(4):615-617. doi: 10.24953/turkjped.2019.04.023. PMID: 31990484
Tanır G, Özgelen Ş, Tuygun N (2008)Kenelerin biyolojik özellikleri, kene ile bulaşan hastalıklar ve epidemiyolojik veriler. Çocuk enfeksiyon Dergisi 2(3) 117-123
Dunkman WJ, Rycek W, Manning MW. What Does a Red Meat Allergy Have to Do With Anesthesia? Perioperative Management of Alpha-Gal Syndrome. Anesth Analg. 2019 Nov;129(5):1242-1248. doi: 10.1213/ANE.0000000000003460. PMID: 29847378.

Saman nezlesi (alerjik rinit)

Liva GA, Karatzanis AD, Prokopakis EP. Review of Rhinitis: Classification, Types, Pathophysiology. J Clin Med. 2021 Jul 19;10(14):3183. doi: 10.3390/jcm10143183. PMID: 34300349; PMCID: PMC8303640.
Mayo-Yáñez M, Díaz-Díaz A, Vázquez-Barro JC, Herranz González-Botas J, Figueroa A, Martín-Martín CS. Relationship between allergic rhinitis and diamine oxidase activity: A preliminary report. Allergol Select. 2021 Jun 18;5:187-194. doi: 10.5414/ALS400537. PMID: 34235375; PMCID: PMC8240126.
Aghili A, Rezaeian A. Predictive Value of the Serum Diamine Oxidase Level in the Diagnosis of Seasonal Allergic Rhinitis. Iran J Immunol. 2022 Dec;19(4):395-403. doi: 10.22034/IJI.2022.95336.2358. PMID: 36585881.

Astım

Barcik W, Pugin B, Westermann P, Perez NR, Ferstl R, Wawrzyniak M, Smolinska S, Jutel M, Hessel EM, Michalovich D, Akdis CA, Frei R, O’Mahony L. Histamine-secreting microbes are increased in the gut of adult asthma patients. J Allergy Clin Immunol. 2016 Nov;138(5):1491-1494.e7. doi: 10.1016/j.jaci.2016.05.049. Epub 2016 Jul 27. PMID: 27576125.
Vassilopoulou E, Konstantinou GN, Dimitriou A, Manios Y, Koumbi L, Papadopoulos NG. The Impact of Food Histamine Intake on Asthma Activity: A Pilot Study. Nutrients. 2020;12(11):3402. Published 2020 Nov 5. doi:10.3390/nu12113402
Berentzen NE, van Stokkom VL, Gehring U, Koppelman GH, Schaap LA, Smit HA, Wijga AH. Associations of sugar-containing beverages with asthma prevalence in 11-year-old children: the PIAMA birth cohort. Eur J Clin Nutr. 2015 Mar;69(3):303-8. doi: 10.1038/ejcn.2014.153. Epub 2014 Aug 13. PMID: 25117998.
Nagel G, Linseisen J. Dietary intake of fatty acids, antioxidants and selected food groups and asthma in adults. Eur J Clin Nutr. 2005 Jan;59(1):8-15. doi: 10.1038/sj.ejcn.1602025. PMID: 15329676.
Yamauchi K, Ogasawara M. The Role of Histamine in the Pathophysiology of Asthma and the Clinical Efficacy of Antihistamines in Asthma Therapy. Int J Mol Sci. 2019;20(7):1733. Published 2019 Apr 8. doi:10.3390/ijms20071733
Robinson DS. The role of the mast cell in asthma: induction of airway hyperresponsiveness by interaction with smooth muscle? J Allergy Clin Immunol. 2004 Jul;114(1):58-65. doi: 10.1016/j.jaci.2004.03.034. PMID: 15241345.
Theoharides TC, Enakuaa S, Sismanopoulos N, Asadi S, Papadimas EC, Angelidou A, Alysandratos KD. Contribution of stress to asthma worsening through mast cell activation. Ann Allergy Asthma Immunol. 2012 Jul;109(1):14-9. doi: 10.1016/j.anai.2012.03.003. Epub 2012 Mar 22. PMID: 22727152.
Bradding P. Mechanisms of Mast Cell Activation in Severe Asthma: Beyond IgE. Am J Respir Crit Care Med. 2022 Feb 15;205(4):375-377. doi: 10.1164/rccm.202110-2322ED. PMID: 34856107; PMCID: PMC8886944.
Guilleminault L, Williams EJ, Scott HA, Berthon BS, Jensen M, Wood LG. Diet and Asthma: Is It Time to Adapt Our Message?. Nutrients. 2017;9(11):1227. Published 2017 Nov 8. doi:10.3390/nu9111227

Kronik ürtiker

Wagner N, Dirk D, Peveling-Oberhag A, Reese I, Rady-Pizarro U, Mitzel H, Staubach P. A Popular myth – low-histamine diet improves chronic spontaneous urticaria – fact or fiction? J Eur Acad Dermatol Venereol. 2017 Apr;31(4):650-655. doi: 10.1111/jdv.13966. Epub 2016 Oct 7. PMID: 27624921.
Son JH, Chung BY, Kim HO, Park CW. A Histamine-Free Diet Is Helpful for Treatment of Adult Patients with Chronic Spontaneous Urticaria. Ann Dermatol. 2018 Apr;30(2):164-172. doi: 10.5021/ad.2018.30.2.164. Epub 2018 Feb 21. PMID: 29606813; PMCID: PMC5839887

Nikel alerjisi

Borghini R, De Amicis N, Bella A, Greco N, Donato G, Picarelli A. Beneficial Effects of a Low-Nickel Diet on Relapsing IBS-Like and Extraintestinal Symptoms of Celiac Patients during a Proper Gluten-Free Diet: Nickel Allergic Contact Mucositis in Suspected Non-Responsive Celiac Disease. Nutrients. 2020 Jul 29;12(8):2277. doi: 10.3390/nu12082277. PMID: 32751300; PMCID: PMC7468824
Antico A, Soana R. Nickel sensitization and dietary nickel are a substantial cause of symptoms provocation in patients with chronic allergic-like dermatitis syndromes. Allergy Rhinol (Providence). 2015;6(1):56-63. doi:10.2500/ar.2015.6.0109
Walsh ML, Smith VH, King CM. Type 1 and type IV hypersensitivity to nickel. Australas J Dermatol. 2010 Nov;51(4):285-6. doi: 10.1111/j.1440-0960.2010.00664.x. PMID: 21198528.
Zambelli B, Ciurli S. Nickel and human health. Met Ions Life Sci. 2013;13:321-57. doi: 10.1007/978-94-007-7500-8_10. PMID: 24470096. Saito M, Arakaki R, Yamada A, Tsunematsu T, Kudo Y, Ishimaru N. Molecular Mechanisms of Nickel Allergy. Int J Mol Sci. 2016;17(2):202. Published 2016 Feb 2. doi:10.3390/ijms17020202

Kontakt dermatit ve Diğer tip IV Alerjiler

Uter W, Werfel T, White IR, Johansen JD. Contact Allergy: A Review of Current Problems from a Clinical Perspective. Int J Environ Res Public Health. 2018 May 29;15(6):1108. doi: 10.3390/ijerph15061108. PMID: 29844295; PMCID: PMC6025382.
Kodumudi, Vijay, and Hao Feng. “Contact dermatitis and nutrition.” Clinics in Dermatology 40.2 (2022): 145-149.

Batı tipi beslenme

Guerville M, Leroy A, Sinquin A, Laugerette F, Michalski MC, Boudry G. Western-diet consumption induces alteration of barrier function mechanisms in the ileum that correlates with metabolic endotoxemia in rats. Am J Physiol Endocrinol Metab. 2017 Aug 1;313(2):E107-E120. doi: 10.1152/ajpendo.00372.2016. Epub 2017 Apr 11. PMID: 28400412.
Valentina Volynets, Sandrine Louis, Dominik Pretz, Lisa Lang, Maureen J Ostaff, Jan Wehkamp, Stephan C Bischoff, Intestinal Barrier Function and the Gut Microbiome Are Differentially Affected in Mice Fed a Western-Style Diet or Drinking Water Supplemented with Fructose, The Journal of Nutrition, Volume 147, Issue 5, May 2017, Pages 770–780, https://doi.org/10.3945/jn.116.242859

Gluten/ çölyak hastalığı/ non çölyak gluten hassasiyeti

Akhondi H, Ross AB. Gluten And Associated Medical Problems. 2021 Jul 6. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan–. PMID: 30860740.
Schnedl WJ, Lackner S, Enko D, Schenk M, Mangge H, Holasek SJ. Non-celiac gluten sensitivity: people without celiac disease avoiding gluten-is it due to histamine intolerance? Inflamm Res. 2018 Apr;67(4):279-284. doi: 10.1007/s00011-017-1117-4. Epub 2017 Nov 27. PMID: 29181545.
Griauzdaitė K, Maselis K, Žvirblienė A, Vaitkus A, Jančiauskas D, Banaitytė-Baleišienė I, Kupčinskas L, Rastenytė D. Associations between migraine, celiac disease, non-celiac gluten sensitivity and activity of diamine oxidase. Med Hypotheses. 2020 Sep;142:109738. doi: 10.1016/j.mehy.2020.109738. Epub 2020 Apr 11. PMID: 32416409.
Schnedl WJ, Mangge H, Schenk M, Enko D. Non-responsive celiac disease may coincide with additional food intolerance/malabsorption, including histamine intolerance. Med Hypotheses. 2021 Jan;146:110404. doi: 10.1016/j.mehy.2020.110404. Epub 2020 Nov 21. PMID: 33268003.
Antiga E, Maglie R, Quintarelli L, et al. Dermatitis Herpetiformis: Novel Perspectives. Front Immunol. 2019;10:1290. Published 2019 Jun 11. doi:10.3389/fimmu.2019.01290
Laurikka P, Nurminen S, Kivelä L, Kurppa K. Extraintestinal Manifestations of Celiac Disease: Early Detection for Better Long-Term Outcomes. Nutrients. 2018;10(8):1015. Published 2018 Aug 3. doi:10.3390/nu10081015
Vici G, Camilletti D, Polzonetti V. Possible Role of Vitamin D in Celiac Disease Onset. Nutrients. 2020;12(4):1051. Published 2020 Apr 10. doi:10.3390/nu12041051
De Palma G, Nadal I, Medina M, et al. Intestinal dysbiosis and reduced immunoglobulin-coated bacteria associated with coeliac disease in children. BMC Microbiol. 2010;10:63. Published 2010 Feb 24. doi:10.1186/1471-2180-10-63
Frossi B, De Carli M, Calabrò A. Coeliac Disease and Mast Cells. Int J Mol Sci. 2019;20(14):3400. Published 2019 Jul 11. doi:10.3390/ijms20143400
Frossi B, Tripodo C, Guarnotta C, et al. Mast cells are associated with the onset and progression of celiac disease. J Allergy Clin Immunol. 2017;139(4):1266-1274.e1. doi:10.1016/j.jaci.2016.08.011
Wierdsma NJ, van Bokhorst-de van der Schueren MA, Berkenpas M, Mulder CJ, van Bodegraven AA. Vitamin and mineral deficiencies are highly prevalent in newly diagnosed celiac disease patients. Nutrients. 2013;5(10):3975-3992. Published 2013 Sep 30. doi:10.3390/nu5103975
Halfdanarson TR, Kumar N, Hogan WJ, Murray JA. Copper deficiency in celiac disease. J Clin Gastroenterol. 2009;43(2):162-164.
McAllister BP, Williams E, Clarke K. A Comprehensive Review of Celiac Disease/Gluten-Sensitive Enteropathies. Clin Rev Allergy Immunol. 2019;57(2):226-243. doi:10.1007/s12016-018-8691-
Monguzzi E, Marabini L, Elli L, et al. Gliadin effect on the oxidative balance and DNA damage: An in-vitro, ex-vivo study. Dig Liver Dis. 2019;51(1):47-54. doi:10.1016/j.dld.2018.06.020
Waszczuk E, Waszczuk K. Gluten, Dysbiosis, and Genetics in Celiac Disease: All Are Important. Dig Dis Sci. 2016;61(9):2761-2762. doi:10.1007/s10620-016-4264-5
Clappison E, Hadjivassiliou M, Zis P. Psychiatric Manifestations of Coeliac Disease, a Systematic Review and Meta-Analysis. Nutrients. 2020;12(1):142. Published 2020 Jan 4. doi:10.3390/nu12010142
Lerner A, Arleevskaya M, Schmiedl A, Matthias T. Microbes and Viruses Are Bugging the Gut in Celiac Disease. Are They Friends or Foes? Front Microbiol. 2017 Aug 2;8:1392. doi: 10.3389/fmicb.2017.01392. PMID: 28824555; PMCID: PMC5539691.
Leonard MM, Sapone A, Catassi C, Fasano A. Celiac Disease and Nonceliac Gluten Sensitivity: A Review. JAMA. 2017;318(7):647–656.
Barbaro MR, Cremon C, Stanghellini V, Barbara G. Recent advances in understanding non-celiac gluten sensitivity. F1000Res. 2018;7:F1000 Faculty Rev-1631. Published 2018 Oct 11.
Croall ID, Hoggard N, Aziz I, Hadjivassiliou M, Sanders DS. Brain fog and non-coeliac gluten sensitivity: Proof of concept brain MRI pilot study. PLoS One. 2020 Aug 28;15(8):e0238283. 10.1371/journal.pone.0238283. PMID: 32857796; PMCID: PMC7454984.
Yelland GW. Gluten-induced cognitive impairment (“brain fog”) in coeliac disease. J Gastroenterol Hepatol. 2017 Mar;32 Suppl 1:90-93. doi: 10.1111/jgh.13706. PMID: 28244662.
Busby E, Bold J, Fellows L, Rostami K. Mood Disorders and Gluten: It’s Not All in Your Mind! A Systematic Review with Meta-Analysis. Nutrients. 2018;10(11):1708. Published 2018 Nov 8. doi:10.3390/nu10111708
Lichtwark IT, Newnham ED, Robinson SR, Shepherd SJ, Hosking P, Gibson PR, Yelland GW. Cognitive impairment in coeliac disease improves on a gluten-free diet and correlates with histological and serological indices of disease severity. Aliment Pharmacol Ther. 2014 Jul;40(2):160-70. doi: 10.1111/apt.12809. Epub 2014 May 28. PMID: 24889390.
Pennisi M, Bramanti A, Cantone M, Pennisi G, Bella R, Lanza G. Neurophysiology of the “Celiac Brain”: Disentangling Gut-Brain Connections. Front Neurosci. 2017;11:498. Published 2017 Sep 5. doi:10.3389/fnins.2017.00498
Mariko Sugiura and Keiji Sugiura, 2012. Immediate Hypersensitivity to a Hydrolyzed Wheat Protein. Asian Journal of Dermatology, 4: 1-5.
Zha K, Brook J, McLaughlin A, Blitshteyn S. Gluten-free diet in postural orthostatic tachycardia syndrome (POTS). Chronic Illn. 2022 Jan 31:17423953221076984. doi: 10.1177/17423953221076984. Epub ahead of print. PMID: 35098721.
Menni S, Boccardi D, Brusasco A. Ichthyosis revealing coeliac disease. Eur J Dermatol. 2000 Jul-Aug;10(5):398-9. PMID: 10882952.
Mumolo MG, Rettura F, Melissari S, Costa F, Ricchiuti A, Ceccarelli L, de Bortoli N, Marchi S, Bellini M. Is Gluten the Only Culprit for Non-Celiac Gluten/Wheat Sensitivity? Nutrients. 2020 Dec 10;12(12):3785. doi: 10.3390/nu12123785. PMID: 33321805; PMCID: PMC7762999.
Massari S, Liso M, De Santis L, Mazzei F, Carlone A, Mauro S, Musca F, Bozzetti MP, Minelli M. Occurrence of nonceliac gluten sensitivity in patients with allergic disease. Int Arch Allergy Immunol. 2011;155(4):389-94. doi: 10.1159/000321196. Epub 2011 Feb 22. PMID: 21346369.
Tursi A, Brandimarte G, Giorgetti G. High prevalence of small intestinal bacterial overgrowth in celiac patients with persistence of gastrointestinal symptoms after gluten withdrawal. Am J Gastroenterol. 2003 Apr;98(4):839-43. doi: 10.1111/j.1572-0241.2003.07379.x. PMID: 12738465.
Mahadev S, Laszkowska M, Sundström J, Björkholm M, Lebwohl B, Green PHR, Ludvigsson JF. Prevalence of Celiac Disease in Patients With Iron Deficiency Anemia-A Systematic Review With Meta-analysis. Gastroenterology. 2018 Aug;155(2):374-382.e1. doi: 10.1053/j.gastro.2018.04.016. Epub 2018 Apr 22. PMID: 29689265; PMCID: PMC7057414.
Kivelä, L., Caminero, A., Leffler, D.A. et al. Current and emerging therapies for coeliac disease. Nat Rev Gastroenterol Hepatol 18, 181–195 (2021).
Sabença, C.; Ribeiro, M.; Sousa, T.d.; Poeta, P.; Bagulho, A.S.; Igrejas, G. Wheat/Gluten-Related Disorders and Gluten-Free Diet Misconceptions: A Review. Foods 2021, 10, 1765. https://doi.org/10.3390/foods10081765
Bojarski C, Tangermann P, Barmeyer C, et al. Prospective, double-blind diagnostic multicentre study of confocal laser endomicroscopy for wheat sensitivity in patients with irritable bowel syndrome. Gut 2022;71:1567-1576.
Drago S., El Asmar R., Di Pierro M., Clemente M.G., Sapone A.T.A., Thakar M., Iacono G., Carroccio A., D’Agate C., Not T., et al. Gliadin, zonulin and gut permeability: Effects on celiac and non-celiac intestinal mucosa and intestinal cell lines. Scand. J. Gastroenterol. 2009;41:408–419. doi: 10.1080/00365520500235334.
Lammers K.M., Lu R., Brownley J., Lu B., Gerard C., Thomas K., Rallabhandi P., Shea-Donohue T., Tamiz A., Alkan S., et al. Gliadin Induces an Increase in Intestinal Permeability and Zonulin Release by Binding to the Chemokine Receptor CXCR3. Gastroenterology. 2008;135:194–204. doi: 10.1053/j.gastro.2008.03.023.

Ekzorfinler

Tyagi, Akanksha, et al. “Food-derived opioid peptides in human health: A review.” International journal of molecular sciences 21.22 (2020): 8825.

İnek sütü ve fermente süt ürünleri

Cabrera-Chávez F, Rouzaud-Sández O, Sotelo-Cruz N, Calderón de la Barca AM. Bovine milk caseins and transglutaminase-treated cereal prolamins are differentially recognized by IgA of celiac disease patients according to their age. J Agric Food Chem. 2009 May 13;57(9):3754-9. doi: 10.1021/jf802596g. PMID: 19290628.
Melnik B. Milk consumption: aggravating factor of acne and promoter of chronic diseases of Western societies. J Dtsch Dermatol Ges. 2009 Apr;7(4):364-70. English, German. doi: 10.1111/j.1610-0387.2009.07019.x. Epub 2008 Feb 20. PMID: 19243483.
Hochwallner H, Schulmeister U, Swoboda I, Spitzauer S, Valenta R. Cow’s milk allergy: from allergens to new forms of diagnosis, therapy and prevention. Methods. 2014 Mar 1;66(1):22-33. doi: 10.1016/j.ymeth.2013.08.005. Epub 2013 Aug 15. PMID: 23954566; PMCID: PMC3969108.
Stępnik, M., & Kurek, M. (2002). The influence of bovine casein-derived exorphins on mast cells in rodents. Revue française d’allergologie et d’immunologie clinique, 42(5), 447-453.
Germundson DL, Smith NA, Vendsel LP, Kelsch AV, Combs CK, Nagamoto-Combs K. Oral sensitization to whey proteins induces age- and sex-dependent behavioral abnormality and neuroinflammatory responses in a mouse model of food allergy: a potential role of mast cells. J Neuroinflammation. 2018 Apr 23;15(1):120. doi: 10.1186/s12974-018-1146-0. PMID: 29685134; PMCID: PMC5913881.
Topal E, Catal F, Soylu N, Ozcan OO, Celiksoy MH, Babayiğit A, Erge D, Karakoç HT, Sancak R. Psychiatric disorders and symptoms severity in pre-school children with cow’s milk allergy. Allergol Immunopathol (Madr). 2016 Sep-Oct;44(5):445-9. doi: 10.1016/j.aller.2016.03.001. Epub 2016 May 27. PMID: 27240441.

Soya ve ürünleri

Doerge DR, Sheehan DM. Goitrogenic and estrogenic activity of soy isoflavones. Environ Health Perspect. 2002;110 Suppl 3(Suppl 3):349-353. doi:10.1289/ehp.02110s3349
Zhao Y, Qin G, Sun Z, Che D, Bao N, Zhang X. Effects of soybean agglutinin on intestinal barrier permeability and tight junction protein expression in weaned piglets. Int J Mol Sci. 2011;12(12):8502-8512. doi:10.3390/ijms12128502
Ahn KM, Han YS, Nam SY, Park HY, Shin MY, Lee SI. Prevalence of soy protein hypersensitivity in cow’s milk protein-sensitive children in Korea. J Korean Med Sci. 2003;18(4):473-477. doi:10.3346/jkms.2003.18.4.473
Klemola T, Kalimo K, Poussa T, et al. Feeding a soy formula to children with cow’s milk allergy: the development of immunoglobulin E-mediated allergy to soy and peanuts. Pediatr Allergy Immunol. 2005;16(8):641-646. doi:10.1111/j.1399-3038.2005.00326.x
Kattan JD, Cocco RR, Järvinen KM. Milk and soy allergy. Pediatr Clin North Am. 2011;58(2):407-x. doi:10.1016/j.pcl.2011.02.005
Ballmer-Weber BK, Vieths S. Soy allergy in perspective. Curr Opin Allergy Clin Immunol. 2008;8(3):270-275. doi:10.1097/ACI.0b013e3282ffb157
Savage JH, Kaeding AJ, Matsui EC, Wood RA. The natural history of soy allergy. J Allergy Clin Immunol. 2010;125(3):683-686. doi:10.1016/j.jaci.2009.12.994
Cabanillas B, Jappe U, Novak N. Allergy to Peanut, Soybean, and Other Legumes: Recent Advances in Allergen Characterization, Stability to Processing and IgE Cross-Reactivity. Mol Nutr Food Res. 2018;62(1):10.1002/mnfr.201700446. doi:10.1002/mnfr.201700446

İşlenmiş gıdalar ve katkı maddeleri

Mancuso C, Barisani D. Food additives can act as triggering factors in celiac disease: Current knowledge based on a critical review of the literature. World J Clin Cases. 2019;7(8):917-927. doi:10.12998/wjcc.v7.i8.917
Hrncirova L, Machova V, Trckova E, Krejsek J, Hrncir T. Food Preservatives Induce Proteobacteria Dysbiosis in Human-Microbiota Associated Nod2-Deficient Mice. Microorganisms. 2019;7(10):383. Published 2019 Sep 23. doi:10.3390/microorganisms7100383
Laudisi F, Stolfi C, Monteleone G. Impact of Food Additives on Gut Homeostasis. Nutrients. 2019;11(10):2334. Published 2019 Oct 1. doi:10.3390/nu11102334
Schwarzfischer M, Rogler G. The Intestinal Barrier-Shielding the Body from Nano- and Microparticles in Our Diet. Metabolites. 2022 Mar 2;12(3):223. doi: 10.3390/metabo12030223. PMID: 35323666; PMCID: PMC8952728.
Vissers E, Wellens J, Sabino J. Ultra-processed foods as a possible culprit for the rising prevalence of inflammatory bowel diseases. Front Med (Lausanne). 2022 Nov 7;9:1058373. doi: 10.3389/fmed.2022.1058373. PMID: 36419796; PMCID: PMC9676654.
Rinninella E, Cintoni M, Raoul P, Gasbarrini A, Mele MC. Food Additives, Gut Microbiota, and Irritable Bowel Syndrome: A Hidden Track. Int J Environ Res Public Health. 2020 Nov 27;17(23):8816. doi: 10.3390/ijerph17238816. PMID: 33260947; PMCID: PMC7730902.
Raoul P, Cintoni M, Palombaro M, Basso L, Rinninella E, Gasbarrini A, Mele MC. Food Additives, a Key Environmental Factor in the Development of IBD through Gut Dysbiosis. Microorganisms. 2022 Jan 13;10(1):167. doi: 10.3390/microorganisms10010167. PMID: 35056616; PMCID: PMC8780106

Boyalar

Leo L, Loong C, Ho XL, Raman MFB, Suan MYT, Loke WM. Occurrence of azo food dyes and their effects on cellular inflammatory responses. Nutrition. 2018 Feb;46:36-40. doi: 10.1016/j.nut.2017.08.010. Epub 2017 Sep 19. PMID: 2929035
Albasher G, Maashi N, Alfarraj S, Almeer R, Albrahim T, Alotibi F, Bin-Jumah M, Mahmoud AM. Perinatal Exposure to Tartrazine Triggers Oxidative Stress and Neurobehavioral Alterations in Mice Offspring. Antioxidants (Basel). 2020 Jan 8;9(1):53. doi: 10.3390/antiox9010053. PMID: 31936188; PMCID: PMC7023231.
Amin KA, Abdel Hameid H 2nd, Abd Elsttar AH. Effect of food azo dyes tartrazine and carmoisine on biochemical parameters related to renal, hepatic function and oxidative stress biomarkers in young male rats. Food Chem Toxicol. 2010 Oct;48(10):2994-9. doi: 10.1016/j.fct.2010.07.039. Epub 2010 Aug 3. PMID: 20678534.

Mikrobiyal tranglutaminaz

Lerner A, Matthias T. Processed Food Additive Microbial Transglutaminase and Its Cross-Linked Gliadin Complexes Are Potential Public Health Concerns in Celiac Disease. Int J Mol Sci. 2020;21(3):1127. Published 2020 Feb 8. doi:10.3390/ijms21031127
Lerner A, Matthias T. Microbial transglutaminase should be considered as an environmental inducer of celiac disease. World J Clin Cases. 2019;7(22):3912-3914. doi:10.12998/wjcc.v7.i22.3912
Lerner A, Matthias T. Microbial Transglutaminase is Beneficial to Food Industries but a Caveat to Public Health. Med One. 2019;4:e190001. https://doi.org/10.20900/mo.20190001
Lerner, Aaron Matthias, Torsten. Microbial transglutaminase: A new potential player in celiac disease Clinical Immunology
10.1016/j.clim.2018.12.008
Lerner A, Matthias T. Changes in intestinal tight junction permeability associated with industrial food additives explain the rising incidence of autoimmune disease. Autoimmun Rev. 2015;14(6):479-489. doi:10.1016/j.autrev.2015.01.009
Cabrera-Chávez F, Rouzaud-Sández O, Sotelo-Cruz N, Calderón de la Barca AM. Transglutaminase treatment of wheat and maize prolamins of bread increases the serum IgA reactivity of celiac disease patients. J Agric Food Chem. 2008 Feb 27;56(4):1387-91. doi: 10.1021/jf0724163. Epub 2008 Jan 15. PMID: 18193828.
Ortiz-Sánchez JP, Cabrera-Chávez F, de la Barca AM. Maize prolamins could induce a gluten-like cellular immune response in some celiac disease patients. Nutrients. 2013 Oct 21;5(10):4174-83. doi: 10.3390/nu5104174. PMID: 24152750; PMCID: PMC3820067.
Lerner A, Benzvi C. Microbial Transglutaminase Is a Very Frequently Used Food Additive and Is a Potential Inducer of Autoimmune/Neurodegenerative Diseases. Toxics. 2021 Sep 25;9(10):233. doi: 10.3390/toxics9100233. PMID: 34678929; PMCID: PMC8537092.

Emülgatör ve surfaktanlar

Mine Y, Zhang JW. Surfactants enhance the tight-junction permeability of food allergens in human intestinal epithelial Caco-2 cells. Int Arch Allergy Immunol. 2003 Feb;130(2):135-42. doi: 10.1159/000069009. PMID: 12673067.

Deamide (deamine) gliadinler

Castan L, Villemin C, Claude M, et al. Acid-Hydrolyzed Gliadins Worsen Food Allergies through Early Sensitization. Mol Nutr Food Res. 2018;62(17):e1800159. doi:10.1002/mnfr.201800159

Hidrolize buğday proteinleri

Sülfitler

Suni tatlandırıcılar

Del Pozo S, Gómez-Martínez S, Díaz LE, Nova E, Urrialde R, Marcos A. Potential Effects of Sucralose and Saccharin on Gut Microbiota: A Review. Nutrients. 2022 Apr 18;14(8):1682. doi: 10.3390/nu14081682. PMID: 35458244; PMCID: PMC9029443.
Shil A, Chichger H. Artificial Sweeteners Negatively Regulate Pathogenic Characteristics of Two Model Gut Bacteria, E. coli and E. faecalis. Int J Mol Sci. 2021 May 15;22(10):5228. doi: 10.3390/ijms22105228. PMID: 34063332; PMCID: PMC8156656.
Shil A, Olusanya O, Ghufoor Z, Forson B, Marks J, Chichger H. Artificial Sweeteners Disrupt Tight Junctions and Barrier Function in the Intestinal Epithelium through Activation of the Sweet Taste Receptor, T1R3. Nutrients. 2020 Jun 22;12(6):1862. doi: 10.3390/nu12061862. PMID: 32580504; PMCID: PMC7353258.

Sitrik asit

Sweis IE, Cressey BC. Potential role of the common food additive manufactured citric acid in eliciting significant inflammatory reactions contributing to serious disease states: A series of four case reports. Toxicol Rep. 2018;5:808-812. Published 2018 Aug 9. doi:10.1016/j.toxrep.2018.08.002

Nitrit/nitratlar

Karragenan

Wu W, Zhou J, Xuan R, Chen J, Han H, Liu J, Niu T, Chen H, Wang F. Dietary κ-carrageenan facilitates gut microbiota-mediated intestinal inflammation. Carbohydr Polym. 2022 Feb 1;277:118830. doi: 10.1016/j.carbpol.2021.118830. Epub 2021 Nov 2. PMID: 34893247.
Borsani B, De Santis R, Perico V, Penagini F, Pendezza E, Dilillo D, Bosetti A, Zuccotti GV, D’Auria E. The Role of Carrageenan in Inflammatory Bowel Diseases and Allergic Reactions: Where Do We Stand? Nutrients. 2021 Sep 27;13(10):3402. doi: 10.3390/nu13103402. PMID: 34684400; PMCID: PMC8539934.

Bitkisel savunma proteinleri

Lopes FC, Cavada BS, Pinto VP, Sampaio AH, Gomes JC. Differential effect of plant lectins on mast cells of different origins. Braz J Med Biol Res. 2005 Jun;38(6):935-41. doi: 10.1590/s0100-879×2005000600016. Epub 2005 Jun 1. PMID: 15933788.
Pramod SN, Venkatesh YP, Mahesh PA. Potato lectin activates basophils and mast cells of atopic subjects by its interaction with core chitobiose of cell-bound non-specific immunoglobulin E. Clin Exp Immunol. 2007;148(3):391-401. doi:10.1111/j.1365-2249.2007.03368.x
Barre A, Damme EJMV, Simplicien M, Benoist H, Rougé P. Are Dietary Lectins Relevant Allergens in Plant Food Allergy? Foods. 2020 Nov 24;9(12):1724. doi: 10.3390/foods9121724. PMID: 33255208; PMCID: PMC7760050.
Adamcová A, Laursen KH, Ballin NZ. Lectin Activity in Commonly Consumed Plant-Based Foods: Calling for Method Harmonization and Risk Assessment. Foods. 2021 Nov 13;10(11):2796. doi: 10.3390/foods10112796. PMID: 34829077; PMCID: PMC8618113.
Haas H, Falcone FH, Schramm G, Haisch K, Gibbs BF, Klaucke J, Pöppelmann M, Becker WM, Gabius HJ, Schlaak M. Dietary lectins can induce in vitro release of IL-4 and IL-13 from human basophils. Eur J Immunol. 1999 Mar;29(3):918-27. doi: 10.1002/(SICI)1521-4141(199903)29:03<918::AID-IMMU918>3.0.CO;2-T. PMID: 10092096.
Vojdani A, Afar D, Vojdani E. Reaction of Lectin-Specific Antibody with Human Tissue: Possible Contributions to Autoimmunity. J Immunol Res. 2020 Feb 11;2020:1438957. doi: 10.1155/2020/1438957. PMID: 32104714; PMCID: PMC7036108.
Signorello MG, Ravera S, Leoncini G. Lectin-induced oxidative stress in human platelets. Redox Biol. 2020 May;32:101456. doi: 10.1016/j.redox.2020.101456. Epub 2020 Feb 8. PMID: 32063518; PMCID: PMC7264469.
Ohmori T, Yatomi Y, Wu Y, Osada M, Satoh K, Ozaki Y. Wheat germ agglutinin-induced platelet activation via platelet endothelial cell adhesion molecule-1: involvement of rapid phospholipase C gamma 2 activation by Src family kinases. Biochemistry. 2001 Oct 30;40(43):12992-3001. doi: 10.1021/bi0109459. PMID: 11669637.
Schwarz RE, Wojciechowicz DC, Picon AI, Schwarz MA, Paty PB. Wheatgerm agglutinin-mediated toxicity in pancreatic cancer cells. Br J Cancer. 1999 Aug;80(11):1754-62. doi: 10.1038/sj.bjc.6690593. PMID: 10468292; PMCID: PMC2363124.
Moreno AN, Jamur MC, Oliver C, Roque-Barreira MC. Mast cell degranulation induced by lectins: effect on neutrophil recruitment. Int Arch Allergy Immunol. 2003 Nov;132(3):221-30. doi: 10.1159/000074303. PMID: 14646383.·
Ovelgönne JH, Koninkx JF, Pusztai A, Bardocz S, Kok W, Ewen SW, Hendriks HG, van Dijk JE. Decreased levels of heat shock proteins in gut epithelial cells after exposure to plant lectins. Gut. 2000 May;46(5):679-87. doi: 10.1136/gut.46.5.680. PMID: 10764712; PMCID: PMC1727920.

IBS ve fonksiyonel sindirim sistemi hastalıkları

Tang HY, Jiang AJ, Wang XY, et al. Uncovering the pathophysiology of irritable bowel syndrome by exploring the gut-brain axis: a narrative review. Ann Transl Med. 2021;9(14):1187. doi:10.21037/atm-21-2779
Duncanson K, Burns G, Pryor J, Keely S, Talley NJ. Mechanisms of Food-Induced Symptom Induction and Dietary Management in Functional Dyspepsia. Nutrients. 2021 Mar 28;13(4):1109. doi: 10.3390/nu13041109. PMID: 33800668; PMCID: PMC8066021.
Talley NJ. Changing Paradigms in Functional Gastrointestinal Disorders. Gastroenterol Hepatol (N Y). 2021;17(9):427-430.
So SY, Savidge TC. Sex-Bias in Irritable Bowel Syndrome: Linking Steroids to the Gut-Brain Axis. Front Endocrinol (Lausanne). 2021 May 19;12:684096. doi: 10.3389/fendo.2021.684096. PMID: 34093447; PMCID: PMC8170482.
Spiller, R. Impact of Diet on Symptoms of the Irritable Bowel Syndrome. Nutrients 2021, 13, 575. https://doi.org/10.3390/nu13020575
Hasler WL, Grabauskas G, Singh P, Owyang C. Mast cell mediation of visceral sensation and permeability in irritable bowel syndrome. Neurogastroenterol Motil. 2022 Jul;34(7):e14339. doi: 10.1111/nmo.14339. Epub 2022 Mar 21. PMID: 35315179; PMCID: PMC9286860.
Aziz MNM, Kumar J, Muhammad Nawawi KN, Raja Ali RA, Mokhtar NM. Irritable Bowel Syndrome, Depression, and Neurodegeneration: A Bidirectional Communication from Gut to Brain. Nutrients. 2021 Aug 31;13(9):3061. doi: 10.3390/nu13093061. PMID: 34578939; PMCID: PMC8468817.
Stanculete MF, Chiarioni G, Dumitrascu DL, Dumitrascu DI, Popa SL. Disorders of the brain-gut interaction and eating disorders. World J Gastroenterol. 2021 Jun 28;27(24):3668-3681. doi: 10.3748/wjg.v27.i24.3668. PMID: 34239277; PMCID: PMC8240049.
Person H, Keefer L. Psychological comorbidity in gastrointestinal diseases: Update on the brain-gut-microbiome axis. Prog Neuropsychopharmacol Biol Psychiatry. 2021 Apr 20;107:110209. doi: 10.1016/j.pnpbp.2020.110209. Epub 2020 Dec 14. PMID: 33326819; PMCID: PMC8382262.
Carco C, Young W, Gearry RB, Talley NJ, McNabb WC, Roy NC. Increasing Evidence That Irritable Bowel Syndrome and Functional Gastrointestinal Disorders Have a Microbial Pathogenesis. Front Cell Infect Microbiol. 2020 Sep 9;10:468. doi: 10.3389/fcimb.2020.00468. PMID: 33014892; PMCID: PMC7509092.
Gurvits GE, Tan A. Burning mouth syndrome. World J Gastroenterol. 2013 Feb 7;19(5):665-72. doi: 10.3748/wjg.v19.i5.665. PMID: 23429751; PMCID: PMC3574592.
Feller L, Fourie J, Bouckaert M, Khammissa RAG, Ballyram R, Lemmer J. Burning Mouth Syndrome: Aetiopathogenesis and Principles of Management. Pain Res Manag. 2017;2017:1926269. doi: 10.1155/2017/1926269. Epub 2017 Oct 18. PMID: 29180911; PMCID: PMC5664327.
Orliaguet M, Misery L. Neuropathic and Psychogenic Components of Burning Mouth Syndrome: A Systematic Review. Biomolecules. 2021 Aug 18;11(8):1237. doi: 10.3390/biom11081237. PMID: 34439903; PMCID: PMC8393188.
Schaeffer, D.F., Kirsch, R. & Riddell, R.H. Mast Cells and Intestinal Motility Disorders (Mastocytic Enteritis/Colitis). Dig Dis Sci 57, 1118–1121 (2012). https://doi.org/10.1007/s10620-012-2123-6
Kim S, Keum B, Byun J, Kim B, Lee K, Yeon J, Lee J, Choi H, Kim E, Jeen Y, Lee H, Chun H, Kim T. Colonic Mucosal Immune Activation in Mice with Ovalbumin-Induced Allergic Airway Disease: Association between Allergic Airway Disease and Irritable Bowel Syndrome. Int J Mol Sci. 2021 Dec 24;23(1):181. doi: 10.3390/ijms23010181. PMID: 35008607; PMCID: PMC8745416.
Lazaridis N, Germanidis G. Current insights into the innate immune system dysfunction in irritable bowel syndrome. Ann Gastroenterol. 2018 Mar-Apr;31(2):171-187. doi: 10.20524/aog.2018.0229. Epub 2018 Jan 18. PMID: 29507464; PMCID: PMC5825947.
Yao X, Yang YS, Cui LH, Sun G, Peng LH, Wang WF, Hyder Q, Zhang XL. The overlap of upper functional gastrointestinal disorders with irritable bowel syndrome in Chinese outpatients: A multicenter study. J Gastroenterol Hepatol. 2016 Sep;31(9):1584-93. doi: 10.1111/jgh.13317. PMID: 26875585.
Borghini R, Puzzono M, Rosato E, Di Tola M, Marino M, Greco F, Picarelli A. Nickel-Related Intestinal Mucositis in IBS-Like Patients: Laser Doppler Perfusion Imaging and Oral Mucosa Patch Test in Use. Biol Trace Elem Res. 2016 Sep;173(1):55-61. doi: 10.1007/s12011-016-0650-2. Epub 2016 Feb 22. PMID: 26899317.
Zanwar VG, Pawar SV, Gambhire PA, et al. Symptomatic improvement with gluten restriction in irritable bowel syndrome: a prospective, randomized, double blinded placebo controlled trial. Intest Res. 2016;14(4):343-350. doi:10.5217/ir.2016.14.4.343
Pretorius L, Smith C. The trace aminergic system: a gender-sensitive therapeutic target for IBS? J Biomed Sci. 2020 Sep 28;27(1):95. doi: 10.1186/s12929-020-00688-1. PMID: 32981524; PMCID: PMC7520957.

Enflamatuar bağırsak hastalıkları

Xie H, He SH. Roles of histamine and its receptors in allergic and inflammatory bowel diseases. World J Gastroenterol. 2005 May 21;11(19):2851-7. doi: 10.3748/wjg.v11.i19.2851. PMID: 15902718; PMCID: PMC4305649.
Honzawa Y., Nakase H., Matsuura M., Chiba T. Clinical significance of serum diamine oxidase activity in inflammatory bowel disease: Importance of evaluation of small intestinal permeability. Inflamm. Bowel Dis. 2011;17:E23–E25. doi: 10.1002/ibd.21588.
Thompson J.S., Burnett D.A., Markin R.S., Vaughan W.P. Intestinal mucosa diamine oxidase activity reflects intestinal involvement in Crohn’s disease. Am. J. Gastroenterol. 1988;83:756–760

Mide asiditesi ve ilaçlar

Yokota T, Matsui H, Matsuura B, Maeyama K, Onji M. Direct effects of proton pump inhibitors on histamine release from rat enterochromaffin-like cells. Eur J Pharmacol. 2003 Nov 28;481(2-3):233-40. doi: 10.1016/j.ejphar.2003.09.011. PMID: 14642791.
Fossmark R, Martinsen TC, Waldum HL. Adverse Effects of Proton Pump Inhibitors-Evidence and Plausibility. Int J Mol Sci. 2019 Oct 21;20(20):5203. doi: 10.3390/ijms20205203. PMID: 31640115; PMCID: PMC6829383.
Jordakieva G, Kundi M, Untersmayr E, Pali-Schöll I, Reichardt B, Jensen-Jarolim E. Country-wide medical records infer increased allergy risk of gastric acid inhibition. Nat Commun. 2019 Jul 30;10(1):3298. doi: 10.1038/s41467-019-10914-6. PMID: 31363098; PMCID: PMC6667461.
Benninga, Marc A., et al. “Drugs in focus: proton pump inhibitors.” Journal of Pediatric Gastroenterology and Nutrition72.5 (2021): 645-653.
Lebwohl B, Spechler SJ, Wang TC, Green PH, Ludvigsson JF. Use of proton pump inhibitors and subsequent risk of celiac disease. Dig Liver Dis. 2014 Jan;46(1):36-40. doi: 10.1016/j.dld.2013.08.128. Epub 2013 Sep 12. PMID: 24035759; PMCID: PMC3947159.

Sindirim sistemi enfeksiyonları, SIBO ve SIFO

Lv, Yp., Teng, Ys., Mao, Fy. et al. Helicobacter pylori-induced IL-33 modulates mast cell responses, benefits bacterial growth, and contributes to gastritis. Cell Death Dis 9, 457 (2018). https://doi.org/10.1038/s41419-018-0493-1
Ma ZF, Majid NA, Yamaoka Y, Lee YY. Food Allergy and Helicobacter pylori Infection: A Systematic Review [published correction appears in Front Microbiol. 2016;7:1232]. Front Microbiol. 2016;7:368. Published 2016 Mar 23. doi:10.3389/fmicb.2016.00368
Liang, ., Ding, X., Wu, Y. et al. Temperature and risk of infectious diarrhea: a systematic review and meta-analysis. Environ Sci Pollut Res 28, 68144–68154 (2021). https://doi.org/10.1007/s11356-021-15395-z
Ibranji, A., Nikolla, E., Loloci, G. et al. A case report on transitory histamine intolerance from strawberry intake in a 15 month old child with acute gastroenteritis. Clin Transl Allergy 5(Suppl 3), P61 (2015). https://doi.org/10.1186/2045-7022-5-S3-P61

Pankratik enzim eksikliği

Brennan GT, Saif MW. Pancreatic Enzyme Replacement Therapy: A Concise Review. JOP. 2019;20(5):121-125. Epub 2019 Jul 30. PMID: 31736680; PMCID: PMC6858980.

Salisilat intoleransı

Tuck CJ, Malakar S, Barrett JS, Muir JG, Gibson PR. Naturally-occurring dietary salicylates in the genesis of functional gastrointestinal symptoms in patients with irritable bowel syndrome: Pilot study. JGH Open. 2021 Jul 21;5(8):871-878. doi: 10.1002/jgh3.12578. PMID: 34386594; PMCID: PMC8341183.
Rechenauer T, Raithel M, Götze T, Siebenlist G, Rückel A, Baenkler HW, Hartmann A, Haller F, Hoerning A. Idiopathic Mast Cell Activation Syndrome With Associated Salicylate Intolerance. Front Pediatr. 2018 Mar 27;6:73. doi: 10.3389/fped.2018.00073. PMID: 29637062; PMCID: PMC5881244.

Benzoat intoleransı

Nettis E, Colanardi MC, Ferrannini A, Tursi A. Sodium benzoate-induced repeated episodes of acute urticaria/angio-oedema: randomized controlled trial. Br J Dermatol. 2004 Oct;151(4):898-902. doi: 10.1111/j.1365-2133.2004.06095.x. PMID: 15491435.
Schnuch A, Lessmann H, Geier J, Uter W. Contact allergy to preservatives. Analysis of IVDK data 1996-2009. Br J Dermatol. 2011 Jun;164(6):1316-25. doi: 10.1111/j.1365-2133.2011.10253.x. Epub 2011 May 11. Erratum in: Br J Dermatol. 2015 Jan;172(1):307. PMID: 21332463.

Glutamat intoleransı

Alim MA, Grujic M, Ackerman PW, Kristiansson P, Eliasson P, Peterson M, Pejler G. Glutamate triggers the expression of functional ionotropic and metabotropic glutamate receptors in mast cells. Cell Mol Immunol. 2021 Oct;18(10):2383-2392. doi: 10.1038/s41423-020-0421-z. Epub 2020 Apr 20. Erratum in: Cell Mol Immunol. 2020 Sep 3;: PMID: 32313211; PMCID: PMC8484602.

Kafein intoleransı

John J, Kodama T, Siegel JM. Caffeine promotes glutamate and histamine release in the posterior hypothalamus. Am J Physiol Regul Integr Comp Physiol. 2014 Sep 15;307(6):R704-10. doi: 10.1152/ajpregu.00114.2014. Epub 2014 Jul 16. PMID: 25031227; PMCID: PMC4166758.
Temple JL, Bernard C, Lipshultz SE, Czachor JD, Westphal JA, Mestre MA. The Safety of Ingested Caffeine: A Comprehensive Review. Front Psychiatry. 2017;8:80. Published 2017 May 26. doi:10.3389/fpsyt.2017.00080
Brathwaite, Joanne & Da Costa, Laura & El-Sohemy, Ahmed. (2011). Catechol- O -Methyltransferase Genotype Is Associated with Self-Reported Increased Heart Rate Following Caffeine Consumption. Journal of Caffeine Research. 1. 123-130. 10.1089/jcr.2011.0015.

Vitamin ve mineral eksiklikleri

Zajac D. Mineral Micronutrients in Asthma. Nutrients. 2021 Nov 10;13(11):4001. doi: 10.3390/nu13114001. PMID: 34836256; PMCID: PMC8625329.
Elmadfa I, Meyer AL. The Role of the Status of Selected Micronutrients in Shaping the Immune Function. Endocr Metab Immune Disord Drug Targets. 2019;19(8):1100-1115. doi: 10.2174/1871530319666190529101816. PMID: 31142256; PMCID: PMC7360912.
Maggini S, Wintergerst ES, Beveridge S, Hornig DH. Selected vitamins and trace elements support immune function by strengthening epithelial barriers and cellular and humoral immune responses. Br J Nutr. 2007 Oct;98 Suppl 1:S29-35. doi: 10.1017/S0007114507832971. PMID: 17922955.
Wollin A, Wang X, Tso P. Nutrients regulate diamine oxidase release from intestinal mucosa. Am J Physiol. 1998 Oct;275(4):R969-75. doi: 10.1152/ajpregu.1998.275.4.R969. PMID: 9756524.
Nurmatov U, Devereux G, Sheikh A. Nutrients and foods for the primary prevention of asthma and allergy: systematic review and meta-analysis. J Allergy Clin Immunol. 2011 Mar;127(3):724-33.e1-30. doi: 10.1016/j.jaci.2010.11.001. Epub 2010 Dec 24. PMID: 21185068.

Bakır

Schuschke DA, Saari JT, West CA, Miller FN. Dietary copper deficiency increases the mast cell population of the rat. Proc Soc Exp Biol Med. 1994 Dec;207(3):274-7. doi: 10.3181/00379727-207-43816. PMID: 7528379.

Folik asit, B12, B6 ve B2 vitaminleri

Mosegaard S, Dipace G, Bross P, Carlsen J, Gregersen N, Olsen RKJ. Riboflavin Deficiency—Implications for General Human Health and Inborn Errors of Metabolism. International Journal of Molecular Sciences. 2020; 21(11):3847. https://doi.org/10.3390/ijms21113847
Lee K, Choi YI, Im ST, Hwang SM, Lee HK, Im JZ, Kim YH, Jung SJ, Park CK. Riboflavin Inhibits Histamine-Dependent Itch by Modulating Transient Receptor Potential Vanilloid 1 (TRPV1). Front Mol Neurosci. 2021 Jun 18;14:643483. doi: 10.3389/fnmol.2021.643483. PMID: 34220447; PMCID: PMC8249943.
Hossain KS, Amarasena S, Mayengbam S. B Vitamins and Their Roles in Gut Health. Microorganisms. 2022 Jun 7;10(6):1168. doi: 10.3390/microorganisms10061168. PMID: 35744686; PMCID: PMC9227236.
Yoshii K, Hosomi K, Sawane K, Kunisawa J. Metabolism of Dietary and Microbial Vitamin B Family in the Regulation of Host Immunity. Front Nutr. 2019 Apr 17;6:48. doi: 10.3389/fnut.2019.00048. PMID: 31058161; PMCID: PMC6478888.

C vitamini

Jarisch R, Weyer D, Ehlert E, Koch CH, Pinkowski E, Jung P, Kähler W, Girgensohn R, Kowalski J, Weisser B, Koch A. Impact of oral vitamin C on histamine levels and seasickness. J Vestib Res. 2014;24(4):281-8. doi: 10.3233/VES-140509. PMID: 25095772.

D vitamini

Fulgheri G, Malinowski B, Bergmann K. Association Between Vitamin D Deficiency and Allergic Diseases. EJIFCC. 2011;22(2):39-44. Published 2011 Jul 20.
Bakhshaee M, Sharifian M, Esmatinia F, Rasoulian B, Mohebbi M. Therapeutic effect of vitamin D supplementation on allergic rhinitis. Eur Arch Otorhinolaryngol. 2019 Oct;276(10):2797-2801. doi: 10.1007/s00405-019-05546-x. Epub 2019 Jul 22. PMID: 31332549.
Boonpiyathad T, Pradubpongsa P, Sangasapaviriya A. Vitamin d supplements improve urticaria symptoms and quality of life in chronic spontaneous urticaria patients: a prospective case-control study. Dermatoendocrinol. 2014 Jul 16;6(1):e29727. doi: 10.4161/derm.29727. PMID: 25346784; PMCID: PMC4203568.
Mirzakhani H, Al-Garawi A, Weiss ST, Litonjua AA. Vitamin D and the development of allergic disease: how important is it?. Clin Exp Allergy. 2015;45(1):114-125. doi:10.1111/cea.12430
Tuchinda, P., Kulthanan, K., Chularojanamontri, L. et al. Relationship between vitamin D and chronic spontaneous urticaria: a systematic review. Clin Transl Allergy 8, 51 (2018). https://doi.org/10.1186/s13601-018-0234-7
Murdaca, G.; Gerosa, A.; Paladin, F.; Petrocchi, L.; Banchero, S.; Gangemi, S. Vitamin D and Microbiota: Is There a Link with Allergies? Int. J. Mol. Sci. 2021, 22, 4288. https://doi.org/10.3390/ijms22084288

A vitamini

Xiao L., Cui T., Liu S., Chen B., Wang Y., Yang T., Li T., Chen J. Vitamin A supplementation improves the intestinal mucosal barrier and facilitates the expression of tight junction proteins in rats with diarrhea. Nutrition. 2019;57:97–108. doi: 10.1016/j.nut.2018.06.007.

Demir

Roth-Walter, F. Compensating functional iron deficiency in patients with allergies with targeted micronutrition. Allergo J Int 30, 130–134 (2021). https://doi.org/10.1007/s40629-021-00171-9
Shaheen SO, Newson RB, Henderson AJ, Emmett PM, Sherriff A, Cooke M; ALSPAC Study Team. Umbilical cord trace elements and minerals and risk of early childhood wheezing and eczema. Eur Respir J. 2004 Aug;24(2):292-7. doi: 10.1183/09031936.04.00117803. PMID: 15332400.
Weigert R, Dosch NC, Bacsik-Campbell ME, Guilbert TW, Coe CL, Kling PJ. Maternal pregnancy weight gain and cord blood iron status are associated with eosinophilia in infancy. J Perinatol. 2015 Aug;35(8):621-6. doi: 10.1038/jp.2015.21. Epub 2015 Apr 2. PMID: 25836316; PMCID: PMC5810929.
Drury KE, Schaeffer M, Silverberg JI. Association Between Atopic Disease and Anemia in US Children. JAMA Pediatr. 2016 Jan;170(1):29-34. doi: 10.1001/jamapediatrics.2015.3065. PMID: 26619045.
Roth-Walter F, Pacios LF, Bianchini R, Jensen-Jarolim E. Linking iron-deficiency with allergy: role of molecular allergens and the microbiome. Metallomics. 2017 Dec 1;9(12):1676-1692. doi: 10.1039/c7mt00241f. Epub 2017 Nov 9. PMID: 29120476.

Magnezyum

Nishio A, Ishiguro S, Miyao N. Specific change of histamine metabolism in acute magnesium-deficient young rats. Drug Nutr Interact. 1987;5(2):89-96. PMID: 3111814.
Takemoto S, Yamamoto A, Tomonaga S, Funaba M, Matsui T. Magnesium deficiency induces the emergence of mast cells in the liver of rats. J Nutr Sci Vitaminol (Tokyo). 2013;59(6):560-3. doi: 10.3177/jnsv.59.560. PMID: 24477254.
Chandrasekaran NC, Weir C, Alfraji S, Grice J, Roberts MS, Barnard RT. Effects of magnesium deficiency–more than skin deep. Exp Biol Med (Maywood). 2014 Oct;239(10):1280-91. doi: 10.1177/1535370214537745. Epub 2014 Jun 13. PMID: 24928863

Çinko

Marone G, Columbo M, de Paulis A, Cirillo R, Giugliano R, Condorelli M. Physiological concentrations of zinc inhibit the release of histamine from human basophils and lung mast cells. Agents Actions. 1986 Apr;18(1-2):103-6. doi: 10.1007/BF01987995. Erratum in: Agents Actions 1986 Aug;18(5-6):607. PMID: 2425567.

Selenyum

Safaralizadeh R, Nourizadeh M, Zare A, Kardar GA, Pourpak Z. Influence of selenium on mast cell mediator release. Biol Trace Elem Res. 2013 Aug;154(2):299-303. doi: 10.1007/s12011-013-9712-x. Epub 2013 Jun 20. PMID: 23784732.
Zhao X, Thijssen S, Chen H, Garssen J, Knippels LMJ, Hogenkamp A. Selenium Modulates the Allergic Response to Whey Protein in a Mouse Model for Cow’s Milk Allergy. Nutrients. 2021 Jul 22;13(8):2479. doi: 10.3390/nu13082479. PMID: 34444651; PMCID: PMC8400770.
Zhao X, Blokhuis BRJ, Redegeld FA, Chang I, Dunham D, Chen H, Nadeau K, Garssen J, Knippels LMJ, Hogenkamp A. Selenomethionine attenuates allergic effector responses in human primary mast cells. Allergy. 2022 Aug;77(8):2552-2555. doi: 10.1111/all.15320. Epub 2022 May 5. PMID: 35451124; PMCID: PMC9710852.

Kalsiyum

Diğer B vitaminleri

Agrawal S, Agrawal A, Said HM. Biotin deficiency enhances the inflammatory response of human dendritic cells. Am J Physiol Cell Physiol. 2016;311(3):C386-C391. doi:10.1152/ajpcell.00141.2016
Bao R, Hesser LA, He Z, Zhou X, Nadeau KC, Nagler CR. Fecal microbiome and metabolome differ in healthy and food-allergic twins. J Clin Invest. 2021 Jan 19;131(2):e141935. doi: 10.1172/JCI141935. PMID: 33463536; PMCID: PMC7810484.
Onodera K, Maeyama K, Watanabe T. Regional changes in brain histamine levels following dietary-induced thiamine deficiency in rats. Jpn J Pharmacol. 1988 Jul;47(3):323-6. doi: 10.1254/jjp.47.323. PMID: 3221531.
Kim HW, Ryoo GH, Jang HY, et al. NAD+-boosting molecules suppress mast cell degranulation and anaphylactic responses in mice. Theranostics. 2022;12(7):3316-3328. Published 2022 Apr 11. doi:10.7150/thno.69684

Omega 3 ve Omega 9 doymamış yağ asitleri

Miyoshi M, Ueno M, Matsuo M, Hamada Y, Takahashi M, Yamamoto M, Yamamoto I, Mikajiri R, Tabuchi S, Wakida K, Yamanishi M, Hirai M, Usami M. Effect of dietary fatty acid and micronutrient intake/energy ratio on serum diamine oxidase activity in healthy women. Nutrition. 2017 Jul-Aug;39-40:67-70. doi: 10.1016/j.nut.2017.03.004. Epub 2017 Mar 28. PMID: 28606572.
Díaz-Perales A, Escribese MM, Garrido-Arandia M, et al. The Role of Sphingolipids in Allergic Disorders. Front Allergy. 2021;2:675557. Published 2021 Jun 14. doi:10.3389/falgy.2021.675557
van den Elsen LW, Meulenbroek LA, van Esch BC, Hofman GA, Boon L, Garssen J, Willemsen LE. CD25+ regulatory T cells transfer n-3 long chain polyunsaturated fatty acids-induced tolerance in mice allergic to cow’s milk protein. Allergy. 2013 Dec;68(12):1562-70. doi: 10.1111/all.12300. PMID: 24410782.

Metilasyon kusuru ve homosistein yüksekliği

Ducker GS, Rabinowitz JD. One-Carbon Metabolism in Health and Disease. Cell Metab. 2017 Jan 10;25(1):27-42. doi: 10.1016/j.cmet.2016.08.009. Epub 2016 Sep 15. PMID: 27641100; PMCID: PMC5353360.
Kumar A, Palfrey HA, Pathak R, Kadowitz PJ, Gettys TW, Murthy SN. The metabolism and significance of homocysteine in nutrition and health. Nutr Metab (Lond). 2017 Dec 22;14:78. doi: 10.1186/s12986-017-0233-z. PMID: 29299040; PMCID: PMC5741875

Kronik stres

Elenkov IJ, Webster EL, Torpy DJ, Chrousos GP. Stress, corticotropin-releasing hormone, glucocorticoids, and the immune/inflammatory response: acute and chronic effects. Ann N Y Acad Sci. 1999 Jun 22;876:1-11; discussion 11-3. doi: 10.1111/j.1749-6632.1999.tb07618.x. PMID: 10415589.
van Laarhoven AI, Walker AL, Wilder-Smith OH, Kroeze S, van Riel PL, van de Kerkhof PC, Kraaimaat FW, Evers AW. Role of induced negative and positive emotions in sensitivity to itch and pain in women. Br J Dermatol. 2012 Aug;167(2):262-9. doi: 10.1111/j.1365-2133.2012.10933.x. Epub 2012 Jun 11. PMID: 22404598.
Najafi P, Misery L, Carré JL, Ben Salem D, Dufor O. Itch Matrixes. Front Med (Lausanne). 2021 Feb 24;8:636904. doi: 10.3389/fmed.2021.636904. PMID: 33718409; PMCID: PMC7943862.
Polloni L, DunnGalvin A, Ferruzza E, Bonaguro R, Lazzarotto F, Toniolo A, Celegato N, Muraro A. Coping strategies, alexithymia and anxiety in young patients with food allergy. Allergy. 2017 Jul;72(7):1054-1060. doi: 10.1111/all.13097. Epub 2017 Jan 11. PMID: 27886387.
Barbosa F, Freitas J, Barbosa A. Alexithymia in chronic urticaria patients. Psychol Health Med. 2011 Mar;16(2):215-24. doi: 10.1080/13548506.2010.525657. PMID: 21328149.
Ogłodek EA, Szota AM, Just MJ, Araszkiewicz A, Szromek AR. Sense of alexithymia in patients with anxiety disorders comorbid with recurrent urticaria. Neuropsychiatr Dis Treat. 2016 Apr 21;12:995-1004. doi: 10.2147/NDT.S94600. PMID: 27143899; PMCID: PMC4844460.
Gıynaş Ayhan, M. , Tekin Kurku, Z. , Eren, İ. & Eren, İ. (2019). Alexithymia, Anxiety and Depression in Patients with Idiopathic Generalized Pruritus . Ankara Medical Journal , 19 (3) , 648-657 . DOI: 10.17098/amj.624491
Li Y, Song Z, Kerr KA, Moeser AJ. Chronic social stress in pigs impairs intestinal barrier and nutrient transporter function, and alters neuro-immune mediator and receptor expression. PLoS One. 2017 Feb 7;12(2):e0171617. doi: 10.1371/journal.pone.0171617. PMID: 28170426; PMCID: PMC5295718.
Fisher JP, Young CN, Fadel PJ. Central sympathetic overactivity: maladies and mechanisms. Auton Neurosci. 2009;148(1-2):5-15.
Trumpff C, Marsland AL, Basualto-Alarcón C, Martin JL, Carroll JE, Sturm G, Vincent AE, Mosharov EV, Gu Z, Kaufman BA, Picard M. Acute psychological stress increases serum circulating cell-free mitochondrial DNA. Psychoneuroendocrinology. 2019 Aug;106:268-276. doi: 10.1016/j.psyneuen.2019.03.026. Epub 2019 Mar 28. PMID: 31029929; PMCID: PMC6589121.
Casaril AM, Dantzer R, Bas-Orth C. Neuronal Mitochondrial Dysfunction and Bioenergetic Failure in Inflammation-Associated Depression. Front Neurosci. 2021 Nov 1;15:725547. doi: 10.3389/fnins.2021.725547. PMID: 34790089; PMCID: PMC8592286.
Hariri AR, Holmes A. Finding translation in stress research. Nat Neurosci. 2015 Oct;18(10):1347-52. doi: 10.1038/nn.4111. Epub 2015 Sep 25. PMID: 26404709; PMCID: PMC4693288.
Wen ZS, Du M, Tang Z, Zhou TY, Zhang ZS, Song HH, Xiang XW, Han XY. Low Molecular Seleno-Aminopolysaccharides Protect the Intestinal Mucosal Barrier of Rats under Weaning Stress. Int J Mol Sci. 2019 Nov 15;20(22):5727. doi: 10.3390/ijms20225727. PMID: 31731602; PMCID: PMC6888692.
O’Mahony SM, Clarke G, Dinan TG, Cryan JF. Irritable Bowel Syndrome and Stress-Related Psychiatric Co-morbidities: Focus on Early Life Stress. Handb Exp Pharmacol. 2017;239:219-246. doi: 10.1007/164_2016_128. PMID: 28233180.
Lupien SJ, McEwen BS, Gunnar MR, Heim C. Effects of stress throughout the lifespan on the brain, behaviour and cognition. Nat Rev Neurosci. 2009 Jun;10(6):434-45. doi: 10.1038/nrn2639. Epub 2009 Apr 29. PMID: 19401723.
Sapolsky RM, Romero LM, Munck AU. How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. Endocr Rev. 2000 Feb;21(1):55-89. doi: 10.1210/edrv.21.1.0389. PMID: 10696570.
Kempuraj D, Mentor S, Thangavel R, Ahmed ME, Selvakumar GP, Raikwar SP, Dubova I, Zaheer S, Iyer SS, Zaheer A. Mast Cells in Stress, Pain, Blood-Brain Barrier, Neuroinflammation and Alzheimer’s Disease. Front Cell Neurosci. 2019 Feb 19;13:54. doi: 10.3389/fncel.2019.00054. PMID: 30837843; PMCID: PMC6389675.

Çocukluk çağı travması

Pohl CS, Medland JE, Moeser AJ. Early-life stress origins of gastrointestinal disease: animal models, intestinal pathophysiology, and translational implications. Am J Physiol Gastrointest Liver Physiol. 2015 Dec 15;309(12):G927-41. doi: 10.1152/ajpgi.00206.2015. Epub 2015 Oct 8. PMID: 26451004; PMCID: PMC4683303.
Pohl CS, Medland JE, Mackey E, Edwards LL, Bagley KD, DeWilde MP, Williams KJ, Moeser AJ. Early weaning stress induces chronic functional diarrhea, intestinal barrier defects, and increased mast cell activity in a porcine model of early life adversity. Neurogastroenterol Motil. 2017 Nov;29(11):10.1111/nmo.13118. doi: 10.1111/nmo.13118. Epub 2017 Jun 1. PMID: 28573751; PMCID: PMC5650513.
Ziegler AL, Blikslager AT. Impaired intestinal barrier function and relapsing digestive disease: Lessons from a porcine model of early life stress. Neurogastroenterol Motil. 2017 Nov;29(11):1-4. doi: 10.1111/nmo.13216. PMID: 29052972; PMCID: PMC5940449.
McClain JL, Mazzotta EA, Maradiaga N, Duque-Wilckens N, Grants I, Robison AJ, Christofi FL, Moeser AJ, Gulbransen BD. Histamine-dependent interactions between mast cells, glia, and neurons are altered following early-life adversity in mice and humans. Am J Physiol Gastrointest Liver Physiol. 2020 Dec 1;319(6):G655-G668. doi: 10.1152/ajpgi.00041.2020. Epub 2020 Sep 30. PMID: 32996781; PMCID: PMC7792668.
Tao E, Zhu Z, Hu C, Long G, Chen B, Guo R, Fang M, Jiang M. Potential Roles of Enterochromaffin Cells in Early Life Stress-Induced Irritable Bowel Syndrome. Front Cell Neurosci. 2022 Mar 15;16:837166. doi: 10.3389/fncel.2022.837166. PMID: 35370559; PMCID: PMC8964523.
Barreau F, Cartier C, Leveque M, Ferrier L, Moriez R, Laroute V, Rosztoczy A, Fioramonti J, Bueno L. Pathways involved in gut mucosal barrier dysfunction induced in adult rats by maternal deprivation: corticotrophin-releasing factor and nerve growth factor interplay. J Physiol. 2007 Apr 1;580(Pt 1):347-56. doi: 10.1113/jphysiol.2006.120907. Epub 2007 Jan 18. PMID: 17234701; PMCID: PMC2075424.

Hipermobil hastalar ve Ehlers Danlos sendromu

Levy HP. Hypermobile Ehlers-Danlos Syndrome. 2004 Oct 22 [Updated 2018 Jun 21]. In: Adam MP, Everman DB, Mirzaa GM, et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2022.
Załęski A, Gawrońska A, Albrecht P, Banasiuk M. Excessive laxity of connective tissue in constipated children. Sci Rep. 2022 Jan 19;12(1):1026. doi: 10.1038/s41598-022-05115-z. PMID: 35046501; PMCID: PMC8770553.
Monaco A, Choi D, Uzun S, Maitland A, Riley B. Association of mast-cell-related conditions with hypermobile syndromes: a review of the literature. Immunol Res. 2022 Aug;70(4):419-431. doi: 10.1007/s12026-022-09280-1. Epub 2022 Apr 21. PMID: 35449490; PMCID: PMC9022617.
Tu Y, Abell TL, Raj SR, Mar PL. Mechanisms and management of gastrointestinal symptoms in postural orthostatic tachycardia syndrome. Neurogastroenterol Motil. 2020 Dec;32(12):e14031. doi: 10.1111/nmo.14031. Epub 2020 Nov 2. PMID: 33140561.
Tai FWD, Palsson OS, Lam CY, Whitehead WE, Sperber AD, Tornblom H, Simren M, Aziz I. Functional gastrointestinal disorders are increased in joint hypermobility-related disorders with concomitant postural orthostatic tachycardia syndrome. Neurogastroenterol Motil. 2020 Dec;32(12):e13975. doi: 10.1111/nmo.13975. Epub 2020 Aug 16. PMID: 32803794.
Song B, Yeh P, Harrell J. Systemic manifestations of Ehlers-Danlos syndrome. Proc (Bayl Univ Med Cent). 2020;34(1):49-53. Published 2020 Aug 26. doi:10.1080/08998280.2020.1805714
Seneviratne SL, Maitland A, Afrin L. Mast cell disorders in Ehlers-Danlos syndrome. Am J Med Genet C Semin Med Genet. 2017 Mar;175(1):226-236. doi: 10.1002/ajmg.c.31555. Epub 2017 Mar 6. PMID: 28261938.
Gazit Y, Jacob G, Grahame R. Ehlers-Danlos Syndrome-Hypermobility Type: A Much Neglected Multisystemic Disorder. Rambam Maimonides Med J. 2016;7(4):e0034. Published 2016 Oct 31. doi:10.5041/RMMJ.10261
Rachel S Brooks, James Grady, Thomas W Lowder, Svetlana Blitshteyn, Prevalence of gastrointestinal, cardiovascular, autonomic and allergic manifestations in hospitalized patients with Ehlers-Danlos syndrome: a case-control study, Rheumatology, Volume 60, Issue 9, September 2021, Pages 4272–4280, https://doi.org/10.1093/rheumatology/keaa926

Kilolar /metabolik sendrom

Trivedi CP, Modi NT, Balothia RK. Effect of intracerebroventricular injection of histamine on blood sugar level and hypothalamo-pituitary adrenal axis of rats. Indian J Physiol Pharmacol. 1976 Jul-Sep;20(3):168-71. PMID: 977086.
Chikahisa S, Harada S, Shimizu N, et al. Mast cell involvement in glucose tolerance impairment caused by chronic mild stress with sleep disturbance. Sci Rep. 2017;7(1):13640. Published 2017 Oct 20. doi:10.1038/s41598-017-14162-w
Pini A, Obara I, Battell E, Chazot PL, Rosa AC. Histamine in diabetes: Is it time to reconsider? Pharmacol Res. 2016 Sep;111:316-324. doi: 10.1016/j.phrs.2016.06.021. Epub 2016 Jun 22. PMID: 27343700.
Rodriguez-Coira J, Villaseñor A, Izquierdo E, Huang M, Barker-Tejeda TC, Radzikowska U, Sokolowska M, Barber D. The Importance of Metabolism for Immune Homeostasis in Allergic Diseases. Front Immunol. 2021 Jul 28;12:692004. doi: 10.3389/fimmu.2021.692004. PMID: 34394086; PMCID: PMC8355700.
Wang J, Shi GP. Mast cell stabilization: novel medication for obesity and diabetes. Diabetes Metab Res Rev. 2011 Nov;27(8):919-24. doi: 10.1002/dmrr.1272. PMID: 22069285; PMCID: PMC3318912.
Liu J, Divoux A, Sun J, et al. Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice. Nat Med. 2009;15(8):940-945. doi:10.1038/nm.1994
Zhang X, Huang Q, Wang X, Deng Z, Li J, Yan X, Jauhiainen M, Metso J, Libby P, Liu J, Shi GP. Dietary cholesterol is essential to mast cell activation and associated obesity and diabetes in mice. Biochim Biophys Acta Mol Basis Dis. 2019 Jun 1;1865(6):1690-1700. doi: 10.1016/j.bbadis.2019.04.006. Epub 2019 Apr 9. PMID: 30978390.
Sick E, Brehin S, André P, Coupin G, Landry Y, Takeda K, Gies JP. Advanced glycation end products (AGEs) activate mast cells. Br J Pharmacol. 2010 Sep;161(2):442-55. doi: 10.1111/j.1476-5381.2010.00905.x. PMID: 20735427; PMCID: PMC2989594.

Kadınlar/hormonlar/menopoz

Zierau O, Zenclussen AC, Jensen F. Role of female sex hormones, estradiol and progesterone, in mast cell behavior. Front Immunol. 2012;3:169. Published 2012 Jun 19. doi:10.3389/fimmu.2012.00169
Jensen F, Woudwyk M, Teles A, et al. Estradiol and progesterone regulate the migration of mast cells from the periphery to the uterus and induce their maturation and degranulation. PLoS One. 2010;5(12):e14409. Published 2010 Dec 22. doi:10.1371/journal.pone.0014409
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Tiroid bezi hastalıkları

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Hava, su ve çevre kirliliği

Ao J, Liu Y, Tang W, Zhang J. Bisphenol S exposure induces intestinal inflammation: An integrated metabolomic and transcriptomic study. Chemosphere. 2022 Apr;292:133510. doi: 10.1016/j.chemosphere.2021.133510. Epub 2021 Dec 31. PMID: 34979203.
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Karolina Nowak, Ewa Jabłońska, Wioletta Ratajczak-Wrona,

Immunomodulatory effects of synthetic endocrine disrupting chemicals on the development and functions of human immune cells,Environment International,Volume 125,2019,Pages 350-364,

Farmer SA, Nelin TD, Falvo MJ, Wold LE. Ambient and household air pollution: complex triggers of disease. Am J Physiol Heart Circ Physiol. 2014;307(4):H467-H476. doi:10.1152/ajpheart.00235.2014
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Natsch A, Hostettler L, Haupt T, Laue H. A critical assessment of the estrogenic potency of benzyl salicylate. Toxicol Rep. 2021 May 4;8:1002-1007. doi: 10.1016/j.toxrep.2021.05.001. PMID: 34408969; PMCID: PMC8363597.
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Ağır metal toksisitesi

Schedle A, Samorapoompichit P, Füreder W, Rausch-Fan XH, Franz A, Sperr WR, Sperr W, Slavicek R, Simak S, Klepetko W, Ellinger A, Ghannadan M, Baghestanian M, Valent P. Metal ion-induced toxic histamine release from human basophils and mast cells. J Biomed Mater Res. 1998 Mar 15;39(4):560-7. doi: 10.1002/(sici)1097-4636(19980315)39:4<560::aid-jbm9>3.0.co;2-h. PMID: 9492216.
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Hasta binalar ve küf mantarları

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Çoklu kimyasal hassasiyet

Zucco GM, Doty RL. Multiple Chemical Sensitivity. Brain Sci. 2021;12(1):46. Published 2021 Dec 29. doi:10.3390/brainsci12010046
Rossi S, Pitidis A. Multiple Chemical Sensitivity: Review of the State of the Art in Epidemiology, Diagnosis, and Future Perspectives. J Occup Environ Med. 2018;60(2):138-146. doi:10.1097/JOM.0000000000001215

Yanan ağız sendromu

Alvarenga-Brant R, Costa FO, Mattos-Pereira G, Esteves-Lima RP, Belém FV, Lai H, Ge L, Gomez RS, Martins CC. Treatments for Burning Mouth Syndrome: A Network Meta-analysis. J Dent Res. 2022 Oct 8:220345221130025. doi: 10.1177/00220345221130025. Epub ahead of print. PMID: 36214096.
Tan HL, Smith JG, Hoffmann J, Renton T. A systematic review of treatment for patients with burning mouth syndrome. Cephalalgia. 2022 Feb;42(2):128-161. doi: 10.1177/03331024211036152. Epub 2021 Aug 18. PMID: 34404247; PMCID: PMC8793318.

Koronavirüs enfeksiyonu/uzun COVID

Weinstock LB, Brook JB, Walters AS, Goris A, Afrin LB, Molderings GJ. Mast cell activation symptoms are prevalent in Long-COVID. Int J Infect Dis. 2021 Sep 23;112:217-226. doi: 10.1016/j.ijid.2021.09.043.
Afrin LB, Weinstock LB, Molderings GJ. Covid-19 hyperinflammation and post-Covid-19 illness may be rooted in mast cell activation syndrome. Int J Infect Dis. 2020;100:327-332. doi:10.1016/j.ijid.2020.09.016
Proal AD, VanElzakker MB. Long COVID or Post-acute Sequelae of COVID-19 (PASC): An Overview of Biological Factors That May Contribute to Persistent Symptoms. Front Microbiol. 2021 Jun 23;12:698169. doi: 10.3389/fmicb.2021.698169. PMID: 34248921; PMCID: PMC8260991.
Lamb LE, Dhar N, Timar R, Wills M, Dhar S, Chancellor MB. COVID-19 inflammation results in urine cytokine elevation and causes COVID-19 associated cystitis (CAC). Med Hypotheses. 2020 Dec;145:110375. doi: 10.1016/j.mehy.2020.110375. Epub 2020 Nov 5. PMID: 33213997; PMCID: PMC7644255.
Lam HY, Tergaonkar V, Kumar AP, Ahn KS. Mast cells: Therapeutic targets for COVID-19 and beyond. IUBMB Life. 2021;73(11):1278-1292. doi:10.1002/iub.2552
Murdaca G, Di Gioacchino M, Greco M, Borro M, Paladin F, Petrarca C, Gangemi S. Basophils and Mast Cells in COVID-19 Pathogenesis. Cells. 2021 Oct 14;10(10):2754. doi: 10.3390/cells10102754. PMID: 34685733; PMCID: PMC8534912.
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Badenoch JB, Rengasamy ER, Watson C, Jansen K, Chakraborty S, Sundaram RD, Hafeez D, Burchill E, Saini A, Thomas L, Cross B, Hunt CK, Conti I, Ralovska S, Hussain Z, Butler M, Pollak TA, Koychev I, Michael BD, Holling H, Nicholson TR, Rogers JP, Rooney AG. Persistent neuropsychiatric symptoms after COVID-19: a systematic review and meta-analysis. Brain Commun. 2021 Dec 17;4(1):fcab297. doi: 10.1093/braincomms/fcab297. PMID: 35169700; PMCID: PMC8833580.
Matsunaga A, Tsuzuki S, Morioka S, Ohmagari N, Ishizaka Y. Long COVID: current status in Japan and knowledge about its molecular background. Glob Health Med. 2022 Apr 30;4(2):83-93. doi: 10.35772/ghm.2022.01013. PMID: 35586759; PMCID: PMC9066464.
Izquierdo-Pujol J, Moron-Lopez S, Dalmau J, Gonzalez-Aumatell A, Carreras-Abad C, Mendez M, Rodrigo C, Martinez-Picado J. Post COVID-19 Condition in Children and Adolescents: An Emerging Problem. Front Pediatr. 2022 May 11;10:894204. doi: 10.3389/fped.2022.894204. PMID: 35633949; PMCID: PMC9130634.
Boaventura P, Macedo S, Ribeiro F, Jaconiano S, Soares P. Post-COVID-19 Condition: Where Are We Now? Life (Basel). 2022 Mar 31;12(4):517. doi: 10.3390/life12040517. PMID: 35455008; PMCID: PMC9029703.
Chippa V, Aleem A, Anjum F. Post Acute Coronavirus (COVID-19) Syndrome. 2022 Jun 19. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan–. PMID: 34033370.
Ahmad SJ, Feigen CM, Vazquez JP, Kobets AJ, Altschul DJ. Neurological Sequelae of COVID-19. J Integr Neurosci. 2022 Apr 6;21(3):77. doi: 10.31083/j.jin2103077. PMID: 35633158.
Piazza M, Di Cicco M, Pecoraro L, Ghezzi M, Peroni D, Comberiati P. Long COVID-19 in Children: From the Pathogenesis to the Biologically Plausible Roots of the Syndrome. Biomolecules. 2022 Apr 8;12(4):556. doi: 10.3390/biom12040556. PMID: 35454144; PMCID: PMC9024951.
Dotan A, David P, Arnheim D, Shoenfeld Y. The autonomic aspects of the post-COVID19 syndrome. Autoimmun Rev. 2022 May;21(5):103071. doi: 10.1016/j.autrev.2022.103071. Epub 2022 Feb 16. PMID: 35182777; PMCID: PMC8848724.
Premraj L, Kannapadi NV, Briggs J, Seal SM, Battaglini D, Fanning J, Suen J, Robba C, Fraser J, Cho SM. Mid and long-term neurological and neuropsychiatric manifestations of post-COVID-19 syndrome: A meta-analysis. J Neurol Sci. 2022 Mar 15;434:120162. doi: 10.1016/j.jns.2022.120162. Epub 2022 Jan 29. PMID: 35121209; PMCID: PMC8798975.
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Becker RC. Autonomic dysfunction in SARS-COV-2 infection acute and long-term implications COVID-19 editor’s page series. J Thromb Thrombolysis. 2021 Oct;52(3):692-707. doi: 10.1007/s11239-021-02549-6. Epub 2021 Aug 17. PMID: 34403043; PMCID: PMC8367772.
Szukiewicz D, Wojdasiewicz P, Watroba M, Szewczyk G. Mast Cell Activation Syndrome in COVID-19 and Female Reproductive Function: Theoretical Background vs. Accumulating Clinical Evidence. J Immunol Res. 2022 Jun 22;2022:9534163. doi: 10.1155/2022/9534163. PMID: 35785029; PMCID: PMC9242765.

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Destekler-besin takviyeleri

Hagan, Marilyn, Bu’Hussain Hayee, and Ana Rodriguez-Mateos. “(Poly) phenols in inflammatory bowel disease and irritable bowel syndrome: a review.” Molecules 26.7 (2021): 1843.
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Yoga meditasyon

Magan D, Yadav RK. Psychoneuroimmunology of Meditation. Ann Neurosci. 2022 Apr;29(2-3):170-176. doi: 10.1177/09727531221109117. Epub 2022 Jul 11. PMID: 36419515; PMCID: PMC9676346.

Nasıl saklayalım? Nasıl pişirelim?

Chung BY, Park SY, Byun YS, et al. Effect of Different Cooking Methods on Histamine Levels in Selected Foods. Ann Dermatol. 2017;29(6):706-714. doi:10.5021/ad.2017.29.6.706

Alkol meselesi

Zimatkin SM, Anichtchik OV. Alcohol-histamine interactions. Alcohol Alcohol. 1999 Mar-Apr;34(2):141-7. doi: 10.1093/alcalc/34.2.141. PMID: 10344773.
Esposito F, Montuori P, Schettino M, et al. Level of Biogenic Amines in Red and White Wines, Dietary Exposure, and Histamine-Mediated Symptoms upon Wine Ingestion. Molecules. 2019;24(19):3629. Published 2019 Oct 8. doi:10.3390/molecules24193629

DAO takviyeleri

Schnedl WJ, Schenk M, Lackner S, Enko D, Mangge H, Forster F. Diamine oxidase supplementation improves symptoms in patients with histamine intolerance. Food Sci Biotechnol. 2019 May 24;28(6):1779-1784. doi: 10.1007/s10068-019-00627-3. PMID: 31807350; PMCID: PMC6859183.